Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3702305..3702923 Replicon chromosome
Accession NZ_CP081782
Organism Escherichia coli strain 0H26

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag J6O44_RS18110 Protein ID WP_001291435.1
Coordinates 3702705..3702923 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag J6O44_RS18105 Protein ID WP_000344800.1
Coordinates 3702305..3702679 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O44_RS18095 (3697394) 3697394..3698587 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
J6O44_RS18100 (3698610) 3698610..3701759 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
J6O44_RS18105 (3702305) 3702305..3702679 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
J6O44_RS18110 (3702705) 3702705..3702923 + 219 WP_001291435.1 HHA domain-containing protein Toxin
J6O44_RS18115 (3703095) 3703095..3703646 + 552 WP_000102564.1 maltose O-acetyltransferase -
J6O44_RS18120 (3703762) 3703762..3704232 + 471 WP_000136192.1 YlaC family protein -
J6O44_RS18125 (3704396) 3704396..3705946 + 1551 WP_001514985.1 cyclic-guanylate-specific phosphodiesterase PdeB -
J6O44_RS18130 (3705988) 3705988..3706341 - 354 WP_000878140.1 DUF1428 domain-containing protein -
J6O44_RS18140 (3706720) 3706720..3707031 + 312 WP_000409911.1 MGMT family protein -
J6O44_RS18145 (3707062) 3707062..3707634 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T213407 WP_001291435.1 NZ_CP081782:3702705-3702923 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T213407 NZ_CP107609:14035-14322 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGATATACTAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT213407 WP_000344800.1 NZ_CP081782:3702305-3702679 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT213407 NZ_CP107609:14309-14623 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References