Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 373401..374019 Replicon chromosome
Accession NC_007613
Organism Shigella boydii Sb227

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag SBO_RS01990 Protein ID WP_001291435.1
Coordinates 373401..373619 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q325D5
Locus tag SBO_RS01995 Protein ID WP_000344809.1
Coordinates 373645..374019 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBO_RS01975 371026..372181 + 1156 WP_094096816.1 IS3 family transposase -
SBO_RS01980 372224..372562 - 339 Protein_349 hypothetical protein -
SBO_RS01985 372678..373229 - 552 WP_000102569.1 maltose O-acetyltransferase -
SBO_RS01990 373401..373619 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
SBO_RS01995 373645..374019 - 375 WP_000344809.1 Hha toxicity modulator TomB Antitoxin
SBO_RS02000 374565..377714 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
SBO_RS02005 377737..378930 - 1194 WP_011379103.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T21340 WP_001291435.1 NC_007613:c373619-373401 [Shigella boydii Sb227]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T21340 NC_007613:c373619-373401 [Shigella boydii Sb227]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14583.42 Da        Isoelectric Point: 4.5934

>AT21340 WP_000344809.1 NC_007613:c374019-373645 [Shigella boydii Sb227]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNYGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT21340 NC_007613:c374019-373645 [Shigella boydii Sb227]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATTATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB Q325D5

References