Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1232967..1233637 Replicon chromosome
Accession NZ_CP081782
Organism Escherichia coli strain 0H26

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag J6O44_RS06095 Protein ID WP_016243791.1
Coordinates 1232967..1233296 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag J6O44_RS06100 Protein ID WP_016243790.1
Coordinates 1233317..1233637 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O44_RS06075 (1228021) 1228021..1228605 + 585 WP_016243792.1 tail fiber assembly protein -
J6O44_RS06080 (1228675) 1228675..1229448 - 774 WP_000355482.1 hypothetical protein -
J6O44_RS06085 (1229855) 1229855..1231288 + 1434 WP_001288444.1 DNA cytosine methyltransferase -
J6O44_RS06090 (1231323) 1231323..1232537 - 1215 WP_012602456.1 type II restriction endonuclease -
J6O44_RS06095 (1232967) 1232967..1233296 - 330 WP_016243791.1 TA system toxin CbtA family protein Toxin
J6O44_RS06100 (1233317) 1233317..1233637 - 321 WP_016243790.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J6O44_RS06105 (1233655) 1233655..1233876 - 222 WP_016243789.1 DUF987 domain-containing protein -
J6O44_RS06110 (1233885) 1233885..1234367 - 483 WP_016243788.1 DNA repair protein RadC -
J6O44_RS06115 (1234376) 1234376..1234834 - 459 WP_016243787.1 antirestriction protein -
J6O44_RS06120 (1234997) 1234997..1235088 - 92 Protein_1197 DUF905 domain-containing protein -
J6O44_RS06125 (1235322) 1235322..1236058 + 737 Protein_1198 IS3 family transposase -
J6O44_RS27450 (1236570) 1236570..1236692 + 123 WP_001406634.1 hypothetical protein -
J6O44_RS06130 (1236731) 1236731..1238239 + 1509 WP_001189123.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1180375..1239473 59098


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(6-105)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12312.37 Da        Isoelectric Point: 9.5496

>T213395 WP_016243791.1 NZ_CP081782:c1233296-1232967 [Escherichia coli]
MKTLPATISRAAKPCLTPVAAWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVDKYELVRIDRKGF
SWQEQTPYLSVVDILRARRSTGLLKAKVK

Download         Length: 330 bp

>T213395 NZ_CP107599:c2619186-2619004 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTTACTATCCCGCATCCTAAAAAGGATTTACCAAGCGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAAGTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11874.45 Da        Isoelectric Point: 7.3231

>AT213395 WP_016243790.1 NZ_CP081782:c1233637-1233317 [Escherichia coli]
MRSNATWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDAAFPHFISQMESMLTTGEMNSRHAHCAILY
HNGFTCEADTLGSCGYVYIAIYSTQR

Download         Length: 321 bp

>AT213395 NZ_CP107599:c2618939-2618535 [Acinetobacter baumannii]
ATGTTGTATCCAATTGCTATTGAGAGAGGTACAGACACCGAGGCCTTTGGTGTCACCGTTCCAGATATTCCAGGATGTTT
TAGCGCAGGCGATACATTAGAGGAAGCTATCGAGAACGTTAAAGAGGCAATTTCTGGCCACTTAGAAATCCTTGCTGAAG
ATGGAGAAGAAATTCCATTAGCATCTGACTTAGCAAAATTTGTAGATGATCCAGATTATAAAGGCATGATCTGGGCTGTT
ACTGAGGTGGATGTTAGTCGTTATCTTGGTAAGCCTGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References