Detailed information of TA system TA213395

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1232967..1233637
• Replicon: chromosome
• Accession: NZ_CP081782
• Organism: Escherichia coli strain 0H26

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: J6O44_RS06095
• Protein ID: WP_016243791.1
• Coordinates: 1232967..1233296 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: J6O44_RS06100
• Protein ID: WP_016243790.1
• Coordinates: 1233317..1233637 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6O44_RS06075 (1228021)	1228021..1228605	+	585	WP_016243792.1	tail fiber assembly protein	-
J6O44_RS06080 (1228675)	1228675..1229448	-	774	WP_000355482.1	hypothetical protein	-
J6O44_RS06085 (1229855)	1229855..1231288	+	1434	WP_001288444.1	DNA cytosine methyltransferase	-
J6O44_RS06090 (1231323)	1231323..1232537	-	1215	WP_012602456.1	type II restriction endonuclease	-
J6O44_RS06095 (1232967)	1232967..1233296	-	330	WP_016243791.1	TA system toxin CbtA family protein	Toxin
J6O44_RS06100 (1233317)	1233317..1233637	-	321	WP_016243790.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
J6O44_RS06105 (1233655)	1233655..1233876	-	222	WP_016243789.1	DUF987 domain-containing protein	-
J6O44_RS06110 (1233885)	1233885..1234367	-	483	WP_016243788.1	DNA repair protein RadC	-
J6O44_RS06115 (1234376)	1234376..1234834	-	459	WP_016243787.1	antirestriction protein	-
J6O44_RS06120 (1234997)	1234997..1235088	-	92	Protein_1197	DUF905 domain-containing protein	-
J6O44_RS06125 (1235322)	1235322..1236058	+	737	Protein_1198	IS3 family transposase	-
J6O44_RS27450 (1236570)	1236570..1236692	+	123	WP_001406634.1	hypothetical protein	-
J6O44_RS06130 (1236731)	1236731..1238239	+	1509	WP_001189123.1	group II intron reverse transcriptase/maturase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1180375..1239473	59098

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-107)

Antitoxin

• Antitoxin CbeA (6-105)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12312.37 Da
• Isoelectric Point: 9.5496

>T213395 WP_016243791.1 NZ_CP081782:c1233296-1232967 [Escherichia coli]
MKTLPATISRAAKPCLTPVAAWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVDKYELVRIDRKGF
SWQEQTPYLSVVDILRARRSTGLLKAKVK

Nucleotide

• Length: 330 bp

>T213395 NZ_CP107599:c2619186-2619004 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTTACTATCCCGCATCCTAAAAAGGATTTACCAAGCGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAAGTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11874.45 Da
• Isoelectric Point: 7.3231

>AT213395 WP_016243790.1 NZ_CP081782:c1233637-1233317 [Escherichia coli]
MRSNATWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDAAFPHFISQMESMLTTGEMNSRHAHCAILY
HNGFTCEADTLGSCGYVYIAIYSTQR

Nucleotide

• Length: 321 bp

>AT213395 NZ_CP107599:c2618939-2618535 [Acinetobacter baumannii]
ATGTTGTATCCAATTGCTATTGAGAGAGGTACAGACACCGAGGCCTTTGGTGTCACCGTTCCAGATATTCCAGGATGTTT
TAGCGCAGGCGATACATTAGAGGAAGCTATCGAGAACGTTAAAGAGGCAATTTCTGGCCACTTAGAAATCCTTGCTGAAG
ATGGAGAAGAAATTCCATTAGCATCTGACTTAGCAAAATTTGTAGATGATCCAGATTATAAAGGCATGATCTGGGCTGTT
ACTGAGGTGGATGTTAGTCGTTATCTTGGTAAGCCTGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG