Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 264271..264790 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP081775 | ||
| Organism | Escherichia coli strain 0H24 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A837F4A9 |
| Locus tag | J6O11_RS25910 | Protein ID | WP_000277490.1 |
| Coordinates | 264271..264555 (-) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A6P1V8C3 |
| Locus tag | J6O11_RS25915 | Protein ID | WP_000124732.1 |
| Coordinates | 264548..264790 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J6O11_RS27405 | 259857..259979 | - | 123 | WP_257606738.1 | hypothetical protein | - |
| J6O11_RS25860 (J6O11_25775) | 260023..260373 | - | 351 | WP_000493399.1 | hypothetical protein | - |
| J6O11_RS25865 (J6O11_25780) | 260517..260978 | - | 462 | WP_223584524.1 | hypothetical protein | - |
| J6O11_RS25870 (J6O11_25785) | 260935..261165 | + | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| J6O11_RS25875 (J6O11_25790) | 261162..261578 | + | 417 | WP_088765932.1 | type II toxin-antitoxin system VapC family toxin | - |
| J6O11_RS25880 (J6O11_25795) | 261676..261816 | - | 141 | WP_045286941.1 | helix-turn-helix domain-containing protein | - |
| J6O11_RS25885 (J6O11_25800) | 261915..262619 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| J6O11_RS25890 (J6O11_25805) | 262682..263203 | + | 522 | Protein_295 | glucose-1-phosphate adenylyltransferase | - |
| J6O11_RS25895 (J6O11_25810) | 263203..263502 | + | 300 | Protein_296 | glycogen/starch synthase | - |
| J6O11_RS25900 | 263503..263721 | + | 219 | Protein_297 | IS110 family transposase | - |
| J6O11_RS25905 (J6O11_25815) | 264041..264133 | + | 93 | Protein_298 | plasmid partition protein ParG | - |
| J6O11_RS25910 (J6O11_25820) | 264271..264555 | - | 285 | WP_000277490.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J6O11_RS25915 (J6O11_25825) | 264548..264790 | - | 243 | WP_000124732.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| J6O11_RS25920 (J6O11_25830) | 265363..266175 | - | 813 | WP_257606735.1 | plasmid replication initiator RepA | - |
| J6O11_RS25925 (J6O11_25835) | 266193..268127 | - | 1935 | Protein_302 | Tn3 family transposase | - |
| J6O11_RS25930 (J6O11_25840) | 268189..268893 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| J6O11_RS25935 (J6O11_25845) | 268955..269065 | - | 111 | Protein_304 | recombinase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..303839 | 303839 | |
| - | inside | IScluster/Tn | - | - | 234304..268893 | 34589 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11005.52 Da Isoelectric Point: 6.2103
>T213388 WP_000277490.1 NZ_CP081775:c264555-264271 [Escherichia coli]
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL
Download Length: 285 bp
>T213388 NZ_CP107595:460564-460953 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTCAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCGCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCCATTAA
TTGATCAACCATTTGAATTTTCAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCGCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCCATTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8875.01 Da Isoelectric Point: 7.0130
>AT213388 WP_000124732.1 NZ_CP081775:c264790-264548 [Escherichia coli]
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV
Download Length: 243 bp
>AT213388 NZ_CP107595:460300-460557 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACTTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA
ATGTCTGAAGAAATGACTTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A837F4A9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V8C3 |