Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 260935..261578 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP081775 | ||
| Organism | Escherichia coli strain 0H24 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | - |
| Locus tag | J6O11_RS25875 | Protein ID | WP_088765932.1 |
| Coordinates | 261162..261578 (+) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | D5KTK7 |
| Locus tag | J6O11_RS25870 | Protein ID | WP_001261282.1 |
| Coordinates | 260935..261165 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J6O11_RS25835 (J6O11_25750) | 256357..256797 | - | 441 | Protein_283 | ISNCY family transposase | - |
| J6O11_RS25840 (J6O11_25755) | 256866..257577 | + | 712 | Protein_284 | IS6 family transposase | - |
| J6O11_RS25845 (J6O11_25760) | 257629..257808 | - | 180 | Protein_285 | hypothetical protein | - |
| J6O11_RS25850 (J6O11_25765) | 257894..259066 | + | 1173 | WP_042111630.1 | IS21-like element IS21 family transposase | - |
| J6O11_RS25855 (J6O11_25770) | 259066..259863 | + | 798 | WP_000544830.1 | IS21-like element IS21 family helper ATPase IstB | - |
| J6O11_RS27405 | 259857..259979 | - | 123 | WP_257606738.1 | hypothetical protein | - |
| J6O11_RS25860 (J6O11_25775) | 260023..260373 | - | 351 | WP_000493399.1 | hypothetical protein | - |
| J6O11_RS25865 (J6O11_25780) | 260517..260978 | - | 462 | WP_223584524.1 | hypothetical protein | - |
| J6O11_RS25870 (J6O11_25785) | 260935..261165 | + | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| J6O11_RS25875 (J6O11_25790) | 261162..261578 | + | 417 | WP_088765932.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| J6O11_RS25880 (J6O11_25795) | 261676..261816 | - | 141 | WP_045286941.1 | helix-turn-helix domain-containing protein | - |
| J6O11_RS25885 (J6O11_25800) | 261915..262619 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| J6O11_RS25890 (J6O11_25805) | 262682..263203 | + | 522 | Protein_295 | glucose-1-phosphate adenylyltransferase | - |
| J6O11_RS25895 (J6O11_25810) | 263203..263502 | + | 300 | Protein_296 | glycogen/starch synthase | - |
| J6O11_RS25900 | 263503..263721 | + | 219 | Protein_297 | IS110 family transposase | - |
| J6O11_RS25905 (J6O11_25815) | 264041..264133 | + | 93 | Protein_298 | plasmid partition protein ParG | - |
| J6O11_RS25910 (J6O11_25820) | 264271..264555 | - | 285 | WP_000277490.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J6O11_RS25915 (J6O11_25825) | 264548..264790 | - | 243 | WP_000124732.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| J6O11_RS25920 (J6O11_25830) | 265363..266175 | - | 813 | WP_257606735.1 | plasmid replication initiator RepA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..303839 | 303839 | |
| - | inside | IScluster/Tn | - | - | 234304..268893 | 34589 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15164.56 Da Isoelectric Point: 6.4581
>T213387 WP_088765932.1 NZ_CP081775:261162-261578 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPDLVLEDWVR
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPDLVLEDWVR
Download Length: 417 bp
>T213387 NZ_CP107593:c2617003-2616821 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTTACTATCCCGCATCCTAAAAAGGATTTACCAAGCGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAAGTGA
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTTACTATCCCGCATCCTAAAAAGGATTTACCAAGCGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAAGTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8756.83 Da Isoelectric Point: 4.4692
>AT213387 WP_001261282.1 NZ_CP081775:260935-261165 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL
Download Length: 231 bp
>AT213387 NZ_CP107593:c2616756-2616352 [Acinetobacter baumannii]
ATGTTGTATCCAATTGCTATTGAGAGAGGTACAGACACCGAGGCCTTTGGTGTCACCGTTCCAGATATTCCAGGATGTTT
TAGCGCAGGCGATACATTAGAGGAAGCTATCGAGAACGTTAAAGAGGCAATTTCTGGCCACTTAGAAATCCTTGCTGAAG
ATGGAGAAGAAATTCCATTAGCATCTGACTTAGCAAAATTTGTAGATGATCCAGATTATAAAGGCATGATCTGGGCTGTT
ACTGAGGTGGATGTTAGTCGTTATCTTGGTAAGCCTGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG
ATGTTGTATCCAATTGCTATTGAGAGAGGTACAGACACCGAGGCCTTTGGTGTCACCGTTCCAGATATTCCAGGATGTTT
TAGCGCAGGCGATACATTAGAGGAAGCTATCGAGAACGTTAAAGAGGCAATTTCTGGCCACTTAGAAATCCTTGCTGAAG
ATGGAGAAGAAATTCCATTAGCATCTGACTTAGCAAAATTTGTAGATGATCCAGATTATAAAGGCATGATCTGGGCTGTT
ACTGAGGTGGATGTTAGTCGTTATCTTGGTAAGCCTGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|