Detailed information of TA system TA213383

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 4337342..4337937
• Replicon: chromosome
• Accession: NZ_CP081774
• Organism: Escherichia coli strain 0H24

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: V0SXT4
• Locus tag: J6O11_RS21265
• Protein ID: WP_000239581.1
• Coordinates: 4337342..4337692 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: L4JJX7
• Locus tag: J6O11_RS21270
• Protein ID: WP_001223213.1
• Coordinates: 4337686..4337937 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6O11_RS21245 (4332791)	4332791..4333813	-	1023	WP_001548970.1	ABC transporter permease	-
J6O11_RS21250 (4333827)	4333827..4335329	-	1503	WP_001095667.1	sugar ABC transporter ATP-binding protein	-
J6O11_RS21255 (4335467)	4335467..4336423	-	957	WP_000265933.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
J6O11_RS21260 (4336733)	4336733..4337263	+	531	WP_000055072.1	inorganic diphosphatase	-
J6O11_RS21265 (4337342)	4337342..4337692	-	351	WP_000239581.1	endoribonuclease toxin ChpB	Toxin
J6O11_RS21270 (4337686)	4337686..4337937	-	252	WP_001223213.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
J6O11_RS21275 (4338149)	4338149..4338490	-	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
J6O11_RS21280 (4338493)	4338493..4342272	-	3780	WP_001548968.1	autotransporter assembly complex protein TamB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12453.41 Da
• Isoelectric Point: 6.2206

>T213383 WP_000239581.1 NZ_CP081774:c4337692-4337342 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T213383 NZ_CP107590:c3499742-3499353 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9331.64 Da
• Isoelectric Point: 4.6509

>AT213383 WP_001223213.1 NZ_CP081774:c4337937-4337686 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT213383 NZ_CP107590:c3500006-3499749 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Toxin

• AlphaFold DB: V0SXT4

Antitoxin

• AlphaFold DB: L4JJX7