Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yafW-ykfI/CbtA-CbeA |
| Location | 3901116..3901795 | Replicon | chromosome |
| Accession | NZ_CP081774 | ||
| Organism | Escherichia coli strain 0H24 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | S1FHS4 |
| Locus tag | J6O11_RS19095 | Protein ID | WP_000854680.1 |
| Coordinates | 3901454..3901795 (+) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | S1EWR7 |
| Locus tag | J6O11_RS19090 | Protein ID | WP_000070396.1 |
| Coordinates | 3901116..3901433 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J6O11_RS19045 (3896555) | 3896555..3897376 | + | 822 | WP_000197388.1 | DUF932 domain-containing protein | - |
| J6O11_RS19050 (3897593) | 3897593..3898294 | + | 702 | WP_000189411.1 | WYL domain-containing protein | - |
| J6O11_RS19055 (3898335) | 3898335..3898571 | + | 237 | WP_001144031.1 | protein YpjK | - |
| J6O11_RS19060 (3898571) | 3898571..3899014 | + | 444 | WP_001547764.1 | lipoprotein YafY | - |
| J6O11_RS19065 (3899037) | 3899037..3899504 | + | 468 | WP_001547765.1 | protein YkfB | - |
| J6O11_RS19070 (3899580) | 3899580..3899819 | + | 240 | WP_000194654.1 | DUF905 family protein | - |
| J6O11_RS19075 (3899917) | 3899917..3900375 | + | 459 | WP_001548150.1 | antirestriction protein | - |
| J6O11_RS19080 (3900391) | 3900391..3900867 | + | 477 | WP_000811693.1 | RadC family protein | - |
| J6O11_RS19085 (3900876) | 3900876..3901097 | + | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
| J6O11_RS19090 (3901116) | 3901116..3901433 | + | 318 | WP_000070396.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
| J6O11_RS19095 (3901454) | 3901454..3901795 | + | 342 | WP_000854680.1 | type IV toxin-antitoxin system toxin YkfI | Toxin |
| J6O11_RS19100 (3902616) | 3902616..3904082 | - | 1467 | WP_000723924.1 | hypothetical protein | - |
| J6O11_RS19105 (3904398) | 3904398..3904817 | - | 420 | WP_001333214.1 | hypothetical protein | - |
| J6O11_RS19110 (3905031) | 3905031..3905117 | - | 87 | Protein_3749 | capsid protein | - |
| J6O11_RS19115 (3905322) | 3905322..3906095 | + | 774 | WP_000355484.1 | hypothetical protein | - |
| J6O11_RS19120 (3906156) | 3906156..3906710 | - | 555 | WP_000905043.1 | site-specific DNA recombinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3876172..3914533 | 38361 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12892.95 Da Isoelectric Point: 9.6543
>T213380 WP_000854680.1 NZ_CP081774:3901454-3901795 [Escherichia coli]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
Download Length: 342 bp
>T213380 NZ_CP081774:3901454-3901795 [Escherichia coli]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11982.62 Da Isoelectric Point: 7.0270
>AT213380 WP_000070396.1 NZ_CP081774:3901116-3901433 [Escherichia coli]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
Download Length: 318 bp
>AT213380 NZ_CP081774:3901116-3901433 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|