Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2703498..2704136 Replicon chromosome
Accession NZ_CP081774
Organism Escherichia coli strain 0H24

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag J6O11_RS13295 Protein ID WP_000813794.1
Coordinates 2703960..2704136 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J6O11_RS13290 Protein ID WP_001270286.1
Coordinates 2703498..2703914 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O11_RS13270 (2698650) 2698650..2699591 - 942 WP_001251313.1 ABC transporter permease -
J6O11_RS13275 (2699592) 2699592..2700605 - 1014 WP_000220434.1 ABC transporter ATP-binding protein -
J6O11_RS13280 (2700623) 2700623..2701768 - 1146 WP_000047430.1 ABC transporter substrate-binding protein -
J6O11_RS13285 (2702013) 2702013..2703419 - 1407 WP_000760630.1 PLP-dependent aminotransferase family protein -
J6O11_RS13290 (2703498) 2703498..2703914 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
J6O11_RS13295 (2703960) 2703960..2704136 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
J6O11_RS13300 (2704358) 2704358..2704588 + 231 WP_000494244.1 YncJ family protein -
J6O11_RS13305 (2704680) 2704680..2706641 - 1962 WP_001488038.1 23S rRNA 5-hydroxycytidine C2501 synthase -
J6O11_RS13310 (2706714) 2706714..2707250 - 537 WP_000429169.1 DNA-binding transcriptional regulator SutR -
J6O11_RS13315 (2707342) 2707342..2708517 + 1176 WP_001236305.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T213378 WP_000813794.1 NZ_CP081774:c2704136-2703960 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T213378 NZ_CP107587:c2927779-2927597 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT213378 WP_001270286.1 NZ_CP081774:c2703914-2703498 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT213378 NZ_CP107587:c2927532-2927128 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References