Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 291317..291836 Replicon plasmid unnamed2
Accession NZ_CP081768
Organism Escherichia coli strain 0H18

Toxin (Protein)


Gene name parE Uniprot ID A0A837F4A9
Locus tag J6O59_RS26060 Protein ID WP_000277490.1
Coordinates 291552..291836 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A6P1V8C3
Locus tag J6O59_RS26055 Protein ID WP_000124732.1
Coordinates 291317..291559 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O59_RS26035 (J6O59_25885) 287042..287152 + 111 Protein_318 recombinase family protein -
J6O59_RS26040 (J6O59_25890) 287214..287918 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
J6O59_RS26045 (J6O59_25895) 287980..289914 + 1935 Protein_320 Tn3 family transposase -
J6O59_RS26050 (J6O59_25900) 289980..290744 + 765 WP_000076190.1 plasmid replication initiator RepA -
J6O59_RS26055 (J6O59_25905) 291317..291559 + 243 WP_000124732.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
J6O59_RS26060 (J6O59_25910) 291552..291836 + 285 WP_000277490.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J6O59_RS26065 (J6O59_25915) 291974..292066 - 93 Protein_324 plasmid partition protein ParG -
J6O59_RS26070 292386..292604 - 219 Protein_325 IS110 family transposase -
J6O59_RS26075 (J6O59_25920) 292605..292904 - 300 Protein_326 glycogen/starch synthase -
J6O59_RS26080 (J6O59_25925) 292904..293425 - 522 Protein_327 glucose-1-phosphate adenylyltransferase -
J6O59_RS26085 (J6O59_25930) 293488..294192 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
J6O59_RS26090 (J6O59_25935) 294291..294431 + 141 WP_045286941.1 helix-turn-helix domain-containing protein -
J6O59_RS26095 (J6O59_25940) 294529..294945 - 417 WP_088765932.1 type II toxin-antitoxin system VapC family toxin -
J6O59_RS26100 (J6O59_25945) 294942..295172 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin -
J6O59_RS26105 (J6O59_25950) 295129..295590 + 462 WP_223584524.1 hypothetical protein -
J6O59_RS26110 (J6O59_25955) 295734..296084 + 351 WP_000493399.1 hypothetical protein -
J6O59_RS27200 296128..296250 + 123 WP_257606738.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..303843 303843
- inside IScluster/Tn - - 287214..302500 15286


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-88)

Antitoxin

Antitoxin ParD

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11005.52 Da        Isoelectric Point: 6.2103

>T213357 WP_000277490.1 NZ_CP081768:291552-291836 [Escherichia coli]
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL

Download         Length: 285 bp

>T213357 NZ_CP107574:c516400-516122 [Pantoea dispersa]
ATGGCCATTTATGTATTGAAGCCCTTCGACCGAAATTTCAAAGGTGACATGATTGCGGACATCAAGCTCTGTCTGGCTGC
CCGCGAATTGATTGCCGGACAGTATGAGGCCAGCCTGGGGGGTGGTGTTTACAAAAAACGCATTCCGCTCGGCGCCGGCA
AAAGCGGCGGAGCCAGAGCGATTGTCGCGTTCAAATCACAAAAACACCTGTTTTTTGTTAACGGTTACGCTAAATCGACC
ACGAAGAGTGGCATACGTGAGATTAACACGAGAGGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8875.01 Da        Isoelectric Point: 7.0130

>AT213357 WP_000124732.1 NZ_CP081768:291317-291559 [Escherichia coli]
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV

Download         Length: 243 bp

>AT213357 NZ_CP107574:c516020-515694 [Pantoea dispersa]
ATGGTTGATCATCTAAAAGATCTGCAGGAAATCGCGCATGATTTTAACCCGCTGGGGGTGGTTAGCGATGAGCTTACCGA
AAAAATCGATTCACGTGTCAGATTACGTGAGCTGCGTACCTCTCTGCCGGTTTTACAACTGATGTCAGGCGAGGCTATTC
GTGAGTTACGTGAGCGACATGGTCTGAGTCAGGCCATGTTAGCCGCCTATATTGGCCTGTCCCCGGCCACCGTGGTGAAA
TGGGAGCGCGAGGAGAAAAAGCCAAATGGCGCTGCGCTGCGCCTGCTTAACCTCATTGATAGAAAGGGTCTTGAGGTATT
GCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F4A9

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V8C3

References