Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 42802..43327 Replicon plasmid unnamed2
Accession NZ_CP081768
Organism Escherichia coli strain 0H18

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag J6O59_RS24680 Protein ID WP_061301055.1
Coordinates 42802..43107 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag J6O59_RS24685 Protein ID WP_061301054.1
Coordinates 43109..43327 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O59_RS24660 (J6O59_24510) 38239..39003 - 765 WP_223584521.1 TnsA endonuclease N-terminal domain-containing protein -
J6O59_RS24665 (J6O59_24515) 39009..39713 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
J6O59_RS24670 (J6O59_24520) 40269..41951 + 1683 WP_103216115.1 methyl-accepting chemotaxis protein -
J6O59_RS24675 (J6O59_24525) 42230..42784 - 555 WP_061301056.1 DUF5710 domain-containing protein -
J6O59_RS24680 (J6O59_24530) 42802..43107 - 306 WP_061301055.1 type II toxin-antitoxin system toxin CcdB Toxin
J6O59_RS24685 (J6O59_24535) 43109..43327 - 219 WP_061301054.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
J6O59_RS24690 (J6O59_24540) 43727..44509 + 783 WP_061301053.1 SprT-like domain-containing protein -
J6O59_RS24695 (J6O59_24545) 44628..45275 + 648 WP_012815856.1 ParA family protein -
J6O59_RS24700 (J6O59_24550) 45316..45549 + 234 WP_011998900.1 hypothetical protein -
J6O59_RS24705 (J6O59_24555) 45588..45932 - 345 WP_041460758.1 hypothetical protein -
J6O59_RS24710 (J6O59_24560) 45989..46462 - 474 WP_011998898.1 thermonuclease family protein -
J6O59_RS24715 (J6O59_24565) 46500..47249 - 750 WP_061301051.1 MobC family replication-relaxation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..303843 303843
- flank IS/Tn - - 39009..39713 704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11409.04 Da        Isoelectric Point: 4.5679

>T213356 WP_061301055.1 NZ_CP081768:c43107-42802 [Escherichia coli]
MQFIIYEYKRVSHYKMFVDVQSDIVDTPGRRMVIPLIESHHLSEIVNSSLFPVVRINDEDYRVMTTELSSVSAAVTGEAI
ADVSSDADAIKNAINLMFWGI

Download         Length: 306 bp

>T213356 NZ_CP107574:253137-253481 [Pantoea dispersa]
ATGCAAGCGACGTTTATTGAGCTTTCCAGCTTTCAGAAATACCGGGCAGATTACCTGAGCGACGATCAATTCAGGCTGTT
TCAGAATATGTTGCTGGCCGACCCCGAAAAGGGCGACGTCATTCCCGATACGGGCGGGCTTCGTAAAGTTCGTTTCAGGG
ATGAACGCCGGAACAAGGGAGCGCGGGGCGGGATTAGAATTATCTATTACTGGACGAATGAAAAAGGCCAGTTCATCCTG
TTCAGCATATATGATAAAGATCAACGCGACGATCTGACCAAACAACAGCGCGATGCCCTGGCGGAGGCGCTGAACGTGAT
CAAAAAGGGGCTGAGACATGACTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8129.10 Da        Isoelectric Point: 7.2032

>AT213356 WP_061301054.1 NZ_CP081768:c43327-43109 [Escherichia coli]
MKHRVSVTVDRENYQVLSSAGINISGLVNEVIGKEARKIKAEQWKADNRAGMEEVANFIAQHGSFAEENRNW

Download         Length: 219 bp

>AT213356 NZ_CP107574:253474-253788 [Pantoea dispersa]
ATGACTGAACGCGACATTTTCAGTGAACTGATGGCGGGTATGCAGGAGCTGAAAGACCACCAGGACGGAAAAATCACGCT
CAAGACCTATAAGGTTAGTAAGCGCGCGCCTGTCACCATTGCGCCGCAGGAGCTGCGCGACGTGCGCGAAAAGCTTAACC
TGTCACAGGCCGTTTTTGCGCACTATCTTCACACGGGCGAAACTACCTATCAGAACTGGGAACAGGGCAGGGCAAAACCT
AACGCTCAGGCCGTACTGCTGATTCGCATGGTGCAGCAAAATCCTGAAACCCTGCAGACTCTCGCGCAATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References