Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4337343..4337938 Replicon chromosome
Accession NZ_CP081767
Organism Escherichia coli strain 0H18

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag J6O59_RS21290 Protein ID WP_000239581.1
Coordinates 4337343..4337693 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag J6O59_RS21295 Protein ID WP_001223213.1
Coordinates 4337687..4337938 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O59_RS21270 (4332792) 4332792..4333814 - 1023 WP_001548970.1 ABC transporter permease -
J6O59_RS21275 (4333828) 4333828..4335330 - 1503 WP_001095667.1 sugar ABC transporter ATP-binding protein -
J6O59_RS21280 (4335468) 4335468..4336424 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
J6O59_RS21285 (4336734) 4336734..4337264 + 531 WP_000055072.1 inorganic diphosphatase -
J6O59_RS21290 (4337343) 4337343..4337693 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
J6O59_RS21295 (4337687) 4337687..4337938 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
J6O59_RS21300 (4338150) 4338150..4338491 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
J6O59_RS21305 (4338494) 4338494..4342273 - 3780 WP_001548968.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T213353 WP_000239581.1 NZ_CP081767:c4337693-4337343 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T213353 NZ_CP107573:c3683933-3683757 [Pantoea dispersa]
TTGAGCAGCAGGGAGCTGATTAGGATGTTGCTTGAACGAGGGTGGATTCTGGATCGTGTTAAAGGAAGCCATCATGTGTT
TGTCCGTGCAGATAAGCCATATCACATCTCGCTTCCTCATCCTGAAAAAGACCTGGCAACCGGAACATTACGTAAGCTAT
TGAAAATGATGGACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT213353 WP_001223213.1 NZ_CP081767:c4337938-4337687 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT213353 NZ_CP107573:c3683638-3683234 [Pantoea dispersa]
ATGAGATTCCCCGTTTATTTGCACAAAACAGAAAACGGCAGCTGGTCAGGTTTCGTACCCGACGTGCAGGGATGTTTTTT
TGCGGGCAACACCGTTGACGAGGCATTGAGCGATGCATTTGGTGCAATCGATGCGCATGTGGAATCGTTAGCGGACGCAG
GCAAGGCCATTCCAAAAGCAGCCAGCGTTGAAACCCATATTAATGATGAAGAGTGCCAGGGAGGTTACTGGGCTTTCGTT
GAGATTGATCTCAGTCGTTACGAAGGTAAAGCGGTGAAGCTGAACATCACCCTGCCGCAAAACTTACTGTCCAAAATCGA
TAGCCACGTAGAAGCACACCGCGAATACGGCTCCCGTAGCGGCTTTCTCGCCGCGCTGGCACGCAGAGAACTGGCAAACA
TCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References