Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4255608..4256184 Replicon chromosome
Accession NZ_CP081767
Organism Escherichia coli strain 0H18

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag J6O59_RS20900 Protein ID WP_001297643.1
Coordinates 4255897..4256184 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A080I7H7
Locus tag J6O59_RS20895 Protein ID WP_000063160.1
Coordinates 4255608..4255910 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O59_RS20880 (4252204) 4252204..4254354 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
J6O59_RS20885 (4254404) 4254404..4254607 + 204 WP_000467859.1 YbdD/YjiX family protein -
J6O59_RS20890 (4254618) 4254618..4255574 + 957 WP_001297640.1 GTPase -
J6O59_RS20895 (4255608) 4255608..4255910 - 303 WP_000063160.1 BrnA antitoxin family protein Antitoxin
J6O59_RS20900 (4255897) 4255897..4256184 - 288 WP_001297643.1 BrnT family toxin Toxin
J6O59_RS20905 (4256383) 4256383..4257079 - 697 Protein_4097 IS1 family transposase -
J6O59_RS20910 (4257394) 4257394..4258626 + 1233 WP_001137031.1 multidrug efflux MFS transporter MdtM -
J6O59_RS20915 (4258667) 4258667..4259947 + 1281 WP_001037390.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4256383..4256592 209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T213352 WP_001297643.1 NZ_CP081767:c4256184-4255897 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T213352 NZ_CP107573:3224931-3225242 [Pantoea dispersa]
ATGCACATTATCTCAAGGAAAGTGTTTAACGAAGCGACACAGAGATTTCCTAATGATGCCGCAGCGCTGGATGCCACTTA
CCGACTATTAAGCGGCCATGATTTTGCCGATCCACAGGCGTTAAAAGCCTGGTTTCCCAGCCTGGATCGCATGAAGTATC
GGGCAAAATGGTGGGTAATTAATGTCGGCGGCAACAATCTCCGGCTGATGTTCTTTGCGGATTTTGTGGCAAAAAGAGTC
TTCGTAAAGCATATCGTGACGCATGCTGAGTATGACAAGCTGGTTAAGCATTACCGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11552.01 Da        Isoelectric Point: 9.4646

>AT213352 WP_000063160.1 NZ_CP081767:c4255910-4255608 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALTNKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp

>AT213352 NZ_CP107573:3225239-3225655 [Pantoea dispersa]
ATGATTAGCGAAGCGATTCAGGCCTCCAACAATCTGATTAAAGCCGTGCCGCTGCTGGGCGGGAGTCAGTCCAGAGCCGA
TTATGAACAGGCGCTTGAACTGGTGGAATACCTGGTTGAGCATCAGCCGGGGCATCCGCTGATCGAGATGCTGGCCGTTA
AAGTCGCGAAGTATGAAGAAACCGCAGCGGAATTTGCCGCGTTTAATGCACGCACTCAGGCGCTGCCGGGCGGCGTGGCG
CTGCTGCGGGTACTGATGGACCAGCACGGTCTGAATCAATCCTCTTTCGTGGCAGAAATCGGTCAGCGTTCGTATGTGAA
TCGCATTCTGAAAGGCGAGCGCAGATTAACGGACAAGCATAAGGCGGCGCTGGCGCGACGCTTTAATCTGCCGTTTGAGG
CATTTCGTGAGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A080I7H7

References