Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3700971..3701589 Replicon chromosome
Accession NZ_CP081767
Organism Escherichia coli strain 0H18

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag J6O59_RS18115 Protein ID WP_001291435.1
Coordinates 3701371..3701589 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag J6O59_RS18110 Protein ID WP_000344800.1
Coordinates 3700971..3701345 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O59_RS18100 (3696060) 3696060..3697253 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
J6O59_RS18105 (3697276) 3697276..3700425 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
J6O59_RS18110 (3700971) 3700971..3701345 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
J6O59_RS18115 (3701371) 3701371..3701589 + 219 WP_001291435.1 HHA domain-containing protein Toxin
J6O59_RS18120 (3701761) 3701761..3702312 + 552 WP_000102564.1 maltose O-acetyltransferase -
J6O59_RS18125 (3702428) 3702428..3702898 + 471 WP_000136192.1 YlaC family protein -
J6O59_RS18130 (3703062) 3703062..3704612 + 1551 WP_001514985.1 cyclic-guanylate-specific phosphodiesterase PdeB -
J6O59_RS18135 (3704654) 3704654..3705007 - 354 WP_000878140.1 DUF1428 domain-containing protein -
J6O59_RS18145 (3705386) 3705386..3705697 + 312 WP_000409911.1 MGMT family protein -
J6O59_RS18150 (3705728) 3705728..3706300 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T213349 WP_001291435.1 NZ_CP081767:3701371-3701589 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T213349 NZ_CP107573:1636909-1637097 [Pantoea dispersa]
ATGGATAGCCGATCGCTAATGGCCGAAATCAGAGCCGACGGCTGGGAGCTGATACGAATTAACGGTAGCCACCATCATTT
TGTCCATCCGACGAAAAAAGGCCTGGTCACGATACCGCATCCAAAAAAGGATTTGCCGATTAAAACGGTAAAAAGTATCA
GAAAACAGGCCGGATTGACCGTCCATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT213349 WP_000344800.1 NZ_CP081767:3700971-3701345 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT213349 NZ_CP107573:1637116-1637526 [Pantoea dispersa]
ATGTTTTACCCCATCGCAATCGAAGCGGGAGATGAAACCACCGCGTACGGCGTTACGGTGCCGGATTTACCCGGCTGTTT
TTCCGCGGGAGATACGCTGGAGGAGGCCGTAAAAAACGCCAAAGAGGCGATTACCGGACATCTGGAGTTAATGGTTGAAC
TCGGCCAGGATATTCCGGCGGTCTCGGACCTTAAATCGCTGATGAAATCGGCGGAGTTTGCTGGTTATGTGTGGGTGCTG
GTGGATGTTGATGTGACCCGAATTCTTGGCGGCTCGGAAAAAATCAATGTCACTCTGCCGAAGTTACTGATTGATCGCAT
CGACCGTTGCGTGGCGACCCATCCGGAATTTAAAACCCGTTCAGGATTTCTGGCGCAGGTTGCGCTGGAGCGCATTGCAA
AAACGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References