Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 78707..79308 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP081764 | ||
| Organism | Escherichia coli strain CX21 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | V0AJ64 |
| Locus tag | J6O46_RS25665 | Protein ID | WP_001216034.1 |
| Coordinates | 78707..79087 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | J6O46_RS25670 | Protein ID | WP_001190712.1 |
| Coordinates | 79087..79308 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J6O46_RS25630 (J6O46_25525) | 74214..74459 | - | 246 | Protein_94 | phage antirepressor KilAC domain-containing protein | - |
| J6O46_RS25635 (J6O46_25530) | 74495..75079 | - | 585 | Protein_95 | transposase | - |
| J6O46_RS25640 (J6O46_25535) | 75132..75836 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| J6O46_RS25645 (J6O46_25540) | 75902..76825 | - | 924 | Protein_97 | terminase | - |
| J6O46_RS25650 (J6O46_25545) | 76911..77363 | - | 453 | WP_053263817.1 | Late promoter-activating protein | - |
| J6O46_RS25655 (J6O46_25550) | 77452..78495 | - | 1044 | WP_054622888.1 | DUF968 domain-containing protein | - |
| J6O46_RS25660 (J6O46_25555) | 78523..78702 | - | 180 | WP_001339207.1 | hypothetical protein | - |
| J6O46_RS25665 (J6O46_25560) | 78707..79087 | - | 381 | WP_001216034.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| J6O46_RS25670 (J6O46_25565) | 79087..79308 | - | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| J6O46_RS25675 (J6O46_25570) | 79475..80179 | + | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| J6O46_RS25680 (J6O46_25575) | 80235..80531 | - | 297 | Protein_104 | IS481 family transposase | - |
| J6O46_RS25685 (J6O46_25580) | 80583..81287 | - | 705 | WP_001572363.1 | IS6-like element IS26 family transposase | - |
| J6O46_RS25690 (J6O46_25585) | 81441..82463 | + | 1023 | WP_001572362.1 | IS110 family transposase | - |
| J6O46_RS25695 (J6O46_25590) | 83509..83838 | + | 330 | WP_000493286.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J6O46_RS25700 (J6O46_25595) | 83819..84100 | + | 282 | WP_000780222.1 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..94675 | 94675 | |
| - | inside | IScluster/Tn | - | - | 74495..84881 | 10386 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13615.32 Da Isoelectric Point: 5.1514
>T213330 WP_001216034.1 NZ_CP081764:c79087-78707 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE
Download Length: 381 bp
>T213330 NZ_CP107548:c1381273-1380950 [Pusillimonas sp. M17]
ATGCGGGGCGACCTGGTAACAATCTCCGTTCAAGGAGATTTTGGCAAGTCTCGTCCTGCTTTGATTATCCAGACCAACCA
TTTTGCGACCCACCCTACATTAACCGTCCTTTTAATCACAAGTACCCTTATCGAGGCTCCTTTGTTTCGCATCACGGTAT
ACCCTGACGACGAAAATCGCTTGCAAGCTCCCTCACAAGTCATGGTGGATAAGGTGATGACAATAAGGCGGGATAAAGCC
GCTCCAGCATTTGGTCGTATAGCGGAAAATACAATGGTGGAGATCGATCGTGCATTGGCGATTTTCCTTGGAATCGCCAA
ATGA
ATGCGGGGCGACCTGGTAACAATCTCCGTTCAAGGAGATTTTGGCAAGTCTCGTCCTGCTTTGATTATCCAGACCAACCA
TTTTGCGACCCACCCTACATTAACCGTCCTTTTAATCACAAGTACCCTTATCGAGGCTCCTTTGTTTCGCATCACGGTAT
ACCCTGACGACGAAAATCGCTTGCAAGCTCCCTCACAAGTCATGGTGGATAAGGTGATGACAATAAGGCGGGATAAAGCC
GCTCCAGCATTTGGTCGTATAGCGGAAAATACAATGGTGGAGATCGATCGTGCATTGGCGATTTTCCTTGGAATCGCCAA
ATGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8133.10 Da Isoelectric Point: 4.7708
>AT213330 WP_001190712.1 NZ_CP081764:c79308-79087 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
Download Length: 222 bp
>AT213330 NZ_CP107548:c1381497-1381273 [Pusillimonas sp. M17]
ATGACAGCGTCACATGTCAACGACAGGGTTCGCAAGTACCGCCAATCGCTCCGCATGGCGGGGCTGCGCCCCATACAAAT
CTGGGTGCCCGATACCCAGCAGCCCAATTTCGGCAAAGAGTGTCACCGTCAATCCATGCTCGCTGCACAAGCCGATGCAA
TGGACACCGAGACATCGACACTGCTGGACGAGGCCCTTAGCGATATCGAAGGCTGGAAAGAGTAA
ATGACAGCGTCACATGTCAACGACAGGGTTCGCAAGTACCGCCAATCGCTCCGCATGGCGGGGCTGCGCCCCATACAAAT
CTGGGTGCCCGATACCCAGCAGCCCAATTTCGGCAAAGAGTGTCACCGTCAATCCATGCTCGCTGCACAAGCCGATGCAA
TGGACACCGAGACATCGACACTGCTGGACGAGGCCCTTAGCGATATCGAAGGCTGGAAAGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V0AJ64 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CJB6 |