Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 71197..71756 | Replicon | plasmid pSD1_197 |
| Accession | NC_007607 | ||
| Organism | Shigella dysenteriae Sd197 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q327A7 |
| Locus tag | SDY_RS23545 | Protein ID | WP_000421263.1 |
| Coordinates | 71481..71756 (+) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q327A8 |
| Locus tag | SDY_RS23540 | Protein ID | WP_001178088.1 |
| Coordinates | 71197..71481 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SDY_RS23500 | 66288..66985 | - | 698 | Protein_75 | IS1 family transposase | - |
| SDY_RS23505 | 67041..67441 | - | 401 | Protein_76 | transposase | - |
| SDY_RS24525 | 67506..67646 | - | 141 | Protein_77 | IS3 family transposase | - |
| SDY_RS23510 | 67701..68234 | - | 534 | Protein_78 | transposase | - |
| SDY_RS23515 | 68349..68987 | - | 639 | WP_000607008.1 | type III secretion system effector OspI | - |
| SDY_RS23520 | 69146..69615 | - | 470 | Protein_80 | IS1 family transposase | - |
| SDY_RS23525 | 69951..70136 | + | 186 | Protein_81 | ATP-binding protein | - |
| SDY_RS23530 | 70236..70445 | - | 210 | Protein_82 | peptidoglycan-binding protein | - |
| SDY_RS23540 | 71197..71481 | + | 285 | WP_001178088.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| SDY_RS23545 | 71481..71756 | + | 276 | WP_000421263.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| SDY_RS24530 | 71888..72025 | - | 138 | WP_000766699.1 | hypothetical protein | - |
| SDY_RS23555 | 72117..72482 | - | 366 | WP_000361391.1 | plasmid partitioning/stability family protein | - |
| SDY_RS23560 | 72485..73053 | - | 569 | Protein_87 | plasmid segregation protein ParM | - |
| SDY_RS23565 | 73061..74151 | + | 1091 | Protein_88 | IS66 family transposase | - |
| SDY_RS23570 | 74527..75220 | - | 694 | Protein_89 | IS1 family transposase | - |
| SDY_RS23575 | 75460..75678 | + | 219 | WP_000813626.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| SDY_RS23580 | 75680..75985 | + | 306 | WP_001159860.1 | type II toxin-antitoxin system toxin CcdB | - |
| SDY_RS23585 | 76021..76116 | + | 96 | Protein_92 | transposase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | ospB / ospC2 / ospD2 / ospF / ospD1 / ipgB2 / ipaH4.5 / ipaH7.8 / ipaH1.4 / ospE2 / ospC1 / ospD3/senA / ospC2 / ospI / ipaH9.8 / ospG / ospC3 / ipaJ / ipaA / ipaD / ipaC / ipaB / ipgC / ipgB1 / ipgA / icsB / ipgD / ipgE / ipgF / mxiG / mxiH / mxiI / mxiJ / mxiK / mxiN / mxiL / mxiM / mxiE / mxiD / mxiC / mxiA / spa15 / spa47 / spa13 / spa32 / spa33 / spa24 / spa9 / spa29 / spa40 / virA / icsA/virG / nleE / icsP/sopA | 1..182726 | 182726 | |
| - | inside | IScluster/Tn | - | ipaH1.4 / ospE2 / ospC1 / ospD3/senA / ospC2 / ospI / ipaH9.8 / ospG | 37326..82140 | 44814 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10792.51 Da Isoelectric Point: 9.8135
>T21332 WP_000421263.1 NC_007607:71481-71756 [Shigella dysenteriae Sd197]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIY
VLRLWYTRENR
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIY
VLRLWYTRENR
Download Length: 276 bp
>T21332 NC_007607:71481-71756 [Shigella dysenteriae Sd197]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTAGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGTACACACGAGAGAACAGGTAG
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTAGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGTACACACGAGAGAACAGGTAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10497.93 Da Isoelectric Point: 6.2150
>AT21332 WP_001178088.1 NC_007607:71197-71481 [Shigella dysenteriae Sd197]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDHPLPVPR
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDHPLPVPR
Download Length: 285 bp
>AT21332 NC_007607:71197-71481 [Shigella dysenteriae Sd197]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|