Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4176043..4176638 Replicon chromosome
Accession NC_007606
Organism Shigella dysenteriae Sd197

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag SDY_RS22035 Protein ID WP_000239577.1
Coordinates 4176288..4176638 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A2X2I2M3
Locus tag SDY_RS22030 Protein ID WP_001223211.1
Coordinates 4176043..4176294 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SDY_RS22020 4171708..4175487 + 3780 WP_000060952.1 autotransporter assembly complex protein TamB -
SDY_RS22025 4175490..4175831 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
SDY_RS22030 4176043..4176294 + 252 WP_001223211.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
SDY_RS22035 4176288..4176638 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
SDY_RS22040 4176715..4177245 - 531 WP_000055075.1 inorganic diphosphatase -
SDY_RS22045 4177555..4178055 + 501 Protein_4253 galactofuranose ABC transporter substrate-binding protein YtfQ -
SDY_RS22055 4178822..4179907 + 1086 Protein_4255 cadaverine/lysine antiporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T21331 WP_000239577.1 NC_007606:4176288-4176638 [Shigella dysenteriae Sd197]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T21331 NC_007606:4176288-4176638 [Shigella dysenteriae Sd197]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTTGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9315.64 Da        Isoelectric Point: 4.4201

>AT21331 WP_001223211.1 NC_007606:4176043-4176294 [Shigella dysenteriae Sd197]
MRITIKRWGNSAGMVIPNVVMKELNLWPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT21331 NC_007606:4176043-4176294 [Shigella dysenteriae Sd197]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTATG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCTACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2I2M3

References