Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3382863..3383617 Replicon chromosome
Accession NC_007606
Organism Shigella dysenteriae Sd197

Toxin (Protein)


Gene name ataT Uniprot ID Q32AN3
Locus tag SDY_RS18010 Protein ID WP_000513068.1
Coordinates 3382863..3383348 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A2X2KZA0
Locus tag SDY_RS18015 Protein ID WP_000801913.1
Coordinates 3383339..3383617 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SDY_RS17980 3378814..3379140 + 327 WP_000371932.1 thiosulfate sulfurtransferase GlpE -
SDY_RS17985 3379185..3380015 + 831 WP_000928722.1 rhomboid family intramembrane serine protease GlpG -
SDY_RS17990 3380032..3380790 + 759 WP_000815099.1 DeoR/GlpR family transcriptional regulator -
SDY_RS17995 3380772..3381281 - 510 Protein_3487 DNA-binding transcriptional regulator RtcR -
SDY_RS18000 3381281..3381781 + 501 Protein_3488 RNA-splicing ligase RtcB -
SDY_RS18005 3381785..3382813 + 1029 WP_024259430.1 RNA 3'-terminal phosphate cyclase -
SDY_RS18010 3382863..3383348 - 486 WP_000513068.1 GNAT family N-acetyltransferase Toxin
SDY_RS18015 3383339..3383617 - 279 WP_000801913.1 DUF1778 domain-containing protein Antitoxin
SDY_RS18020 3383684..3386383 - 2700 WP_000907050.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-92)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17631.53 Da        Isoelectric Point: 9.1197

>T21330 WP_000513068.1 NC_007606:c3383348-3382863 [Shigella dysenteriae Sd197]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRHNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E

Download         Length: 486 bp

>T21330 NC_007606:c3383348-3382863 [Shigella dysenteriae Sd197]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCATTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACATAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10449.00 Da        Isoelectric Point: 4.6336

>AT21330 WP_000801913.1 NC_007606:c3383617-3383339 [Shigella dysenteriae Sd197]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQVK
INALMNRKSPWE

Download         Length: 279 bp

>AT21330 NC_007606:c3383617-3383339 [Shigella dysenteriae Sd197]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGTCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090ND96

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2KZA0

References