Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4298036..4298631 Replicon chromosome
Accession NZ_CP081742
Organism Escherichia coli strain CX15

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag J6O52_RS21050 Protein ID WP_000239581.1
Coordinates 4298036..4298386 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag J6O52_RS21055 Protein ID WP_001223213.1
Coordinates 4298380..4298631 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O52_RS21030 (4293485) 4293485..4294507 - 1023 WP_001548970.1 ABC transporter permease -
J6O52_RS21035 (4294521) 4294521..4296023 - 1503 WP_001095667.1 sugar ABC transporter ATP-binding protein -
J6O52_RS21040 (4296161) 4296161..4297117 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
J6O52_RS21045 (4297427) 4297427..4297957 + 531 WP_000055072.1 inorganic diphosphatase -
J6O52_RS21050 (4298036) 4298036..4298386 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
J6O52_RS21055 (4298380) 4298380..4298631 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
J6O52_RS21060 (4298843) 4298843..4299184 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
J6O52_RS21065 (4299187) 4299187..4302966 - 3780 WP_001548968.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T213291 WP_000239581.1 NZ_CP081742:c4298386-4298036 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T213291 NZ_CP107513:4745031-4745133 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT213291 WP_001223213.1 NZ_CP081742:c4298631-4298380 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT213291 NZ_CP107513:c4745140-4744995 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References