Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2952973..2953627 Replicon chromosome
Accession NC_007606
Organism Shigella dysenteriae Sd197

Toxin (Protein)


Gene name cptA Uniprot ID Q32BV9
Locus tag SDY_RS15680 Protein ID WP_000244779.1
Coordinates 2953220..2953627 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag SDY_RS15675 Protein ID WP_000354046.1
Coordinates 2952973..2953239 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SDY_RS15650 2948287..2949720 - 1434 Protein_3030 6-phospho-beta-glucosidase BglA -
SDY_RS15655 2949765..2950076 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
SDY_RS15665 2951077..2951673 + 597 Protein_3033 hemolysin III family protein -
SDY_RS15670 2951750..2952730 - 981 WP_000886092.1 tRNA-modifying protein YgfZ -
SDY_RS15675 2952973..2953239 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
SDY_RS15680 2953220..2953627 + 408 WP_000244779.1 protein YgfX Toxin
SDY_RS15685 2953667..2954188 - 522 WP_001055874.1 flavodoxin FldB -
SDY_RS15690 2954300..2955196 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
SDY_RS15695 2955221..2955931 + 711 WP_000715209.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
SDY_RS15700 2955937..2957670 + 1734 WP_000813170.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2950325..2950720 395


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.2669

>T21329 WP_000244779.1 NC_007606:2953220-2953627 [Shigella dysenteriae Sd197]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRWILLQQETQR

Download         Length: 408 bp

>T21329 NC_007606:2953220-2953627 [Shigella dysenteriae Sd197]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGTGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT21329 WP_000354046.1 NC_007606:2952973-2953239 [Shigella dysenteriae Sd197]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT21329 NC_007606:2952973-2953239 [Shigella dysenteriae Sd197]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTCAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NWM4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References