Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 768960..769747 Replicon chromosome
Accession NZ_CP081742
Organism Escherichia coli strain CX15

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6L5EGB6
Locus tag J6O52_RS03800 Protein ID WP_032669201.1
Coordinates 769370..769747 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A6L5EE19
Locus tag J6O52_RS03795 Protein ID WP_023567998.1
Coordinates 768960..769319 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O52_RS03750 (764221) 764221..764934 + 714 WP_032669194.1 WYL domain-containing protein -
J6O52_RS03755 (764931) 764931..765566 + 636 WP_020837117.1 hypothetical protein -
J6O52_RS03760 (765605) 765605..766060 + 456 WP_000754598.1 hypothetical protein -
J6O52_RS03765 (766057) 766057..766506 + 450 WP_032669197.1 IrmA family protein -
J6O52_RS03770 (766578) 766578..766809 + 232 Protein_741 DUF905 domain-containing protein -
J6O52_RS03775 (766908) 766908..767729 + 822 WP_032669198.1 DUF932 domain-containing protein -
J6O52_RS03780 (767760) 767760..768203 + 444 WP_032669199.1 antirestriction protein -
J6O52_RS03785 (768215) 768215..768694 + 480 WP_032669200.1 DNA repair protein RadC -
J6O52_RS03790 (768715) 768715..768936 + 222 WP_023567997.1 DUF987 domain-containing protein -
J6O52_RS03795 (768960) 768960..769319 + 360 WP_023567998.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J6O52_RS03800 (769370) 769370..769747 + 378 WP_032669201.1 TA system toxin CbtA family protein Toxin
J6O52_RS03805 (769744) 769744..770235 + 492 WP_032672023.1 DUF5983 family protein -
J6O52_RS03810 (770265) 770265..770468 + 204 WP_032669203.1 DUF957 domain-containing protein -
J6O52_RS03815 (770532) 770532..771380 + 849 WP_032669204.1 DUF4942 domain-containing protein -
J6O52_RS03825 (771683) 771683..772189 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
J6O52_RS03830 (772268) 772268..774109 - 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14157.93 Da        Isoelectric Point: 6.2236

>T213271 WP_032669201.1 NZ_CP081742:769370-769747 [Escherichia coli]
MQTQPLSSTQEATPRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLSSIDILRARKATGLMTRNDYRTVTDITTGKYREVQP

Download         Length: 378 bp

>T213271 NZ_CP107508:c4802170-4801637 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13192.04 Da        Isoelectric Point: 6.3122

>AT213271 WP_023567998.1 NZ_CP081742:768960-769319 [Escherichia coli]
MSNEIPTVNHDITEPWWGLKRSITPCFGARLVQAGNRLHYLADRANITGQFSDADLRYLDQAFPLLLKQLELMLTSGELN
PCHQHCVTLYAKGLTCEADSLGSHGYVYLAIYPTPAATA

Download         Length: 360 bp

>AT213271 NZ_CP107508:c4802447-4802181 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L5EGB6

Antitoxin

Source ID Structure
AlphaFold DB A0A6L5EE19

References