Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 4114391..4114941 | Replicon | chromosome |
Accession | NZ_CP081724 | ||
Organism | Escherichia coli strain CX07 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | D7Y6T6 |
Locus tag | J6O12_RS20150 | Protein ID | WP_001160971.1 |
Coordinates | 4114391..4114705 (-) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | V0VEX8 |
Locus tag | J6O12_RS20155 | Protein ID | WP_000125566.1 |
Coordinates | 4114708..4114941 (-) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
J6O12_RS20125 (4110066) | 4110066..4111352 | + | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
J6O12_RS20130 (4111352) | 4111352..4112341 | + | 990 | WP_000241253.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
J6O12_RS20135 (4112338) | 4112338..4113159 | + | 822 | WP_001065392.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
J6O12_RS20140 (4113162) | 4113162..4113539 | + | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
J6O12_RS20145 (4113546) | 4113546..4114394 | + | 849 | WP_000257189.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
J6O12_RS20150 (4114391) | 4114391..4114705 | - | 315 | WP_001160971.1 | CcdB family protein | Toxin |
J6O12_RS20155 (4114708) | 4114708..4114941 | - | 234 | WP_000125566.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
J6O12_RS20160 (4115027) | 4115027..4115506 | - | 480 | WP_001487721.1 | type 3 dihydrofolate reductase | - |
J6O12_RS20165 (4115698) | 4115698..4117560 | - | 1863 | WP_223610817.1 | glutathione-regulated potassium-efflux system protein KefC | - |
J6O12_RS20170 (4117553) | 4117553..4118083 | - | 531 | WP_000600718.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
J6O12_RS20175 (4118194) | 4118194..4119525 | - | 1332 | WP_001183198.1 | MFS transporter | - |
J6O12_RS20180 (4119583) | 4119583..4119870 | - | 288 | WP_000203741.1 | ferredoxin-like protein FixX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11741.75 Da Isoelectric Point: 9.0851
>T213258 WP_001160971.1 NZ_CP081724:c4114705-4114391 [Escherichia coli]
MQFTVYRSRSRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
MQFTVYRSRSRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
Download Length: 315 bp
>T213258 NZ_CP107504:c49368-48886 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8530.53 Da Isoelectric Point: 5.8062
>AT213258 WP_000125566.1 NZ_CP081724:c4114941-4114708 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
Download Length: 234 bp
>AT213258 NZ_CP107504:c49622-49356 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A241QVQ9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LTM9 |