Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yafW-ykfI/CbtA-CbeA |
| Location | 3866297..3866976 | Replicon | chromosome |
| Accession | NZ_CP081724 | ||
| Organism | Escherichia coli strain CX07 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | S1FHS4 |
| Locus tag | J6O12_RS18895 | Protein ID | WP_000854680.1 |
| Coordinates | 3866635..3866976 (+) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | S1EWR7 |
| Locus tag | J6O12_RS18890 | Protein ID | WP_000070396.1 |
| Coordinates | 3866297..3866614 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J6O12_RS18845 (3861735) | 3861735..3862556 | + | 822 | WP_000197388.1 | DUF932 domain-containing protein | - |
| J6O12_RS18850 (3862773) | 3862773..3863474 | + | 702 | WP_060616110.1 | WYL domain-containing protein | - |
| J6O12_RS18855 (3863515) | 3863515..3863751 | + | 237 | WP_001144031.1 | protein YpjK | - |
| J6O12_RS18860 (3863751) | 3863751..3864194 | + | 444 | WP_000649865.1 | hypothetical protein | - |
| J6O12_RS18865 (3864217) | 3864217..3864684 | + | 468 | WP_001385283.1 | protein YkfB | - |
| J6O12_RS18870 (3864761) | 3864761..3865000 | + | 240 | WP_000194654.1 | DUF905 family protein | - |
| J6O12_RS18875 (3865098) | 3865098..3865556 | + | 459 | WP_000211838.1 | antirestriction protein | - |
| J6O12_RS18880 (3865572) | 3865572..3866048 | + | 477 | WP_001549015.1 | RadC family protein | - |
| J6O12_RS18885 (3866057) | 3866057..3866278 | + | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
| J6O12_RS18890 (3866297) | 3866297..3866614 | + | 318 | WP_000070396.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
| J6O12_RS18895 (3866635) | 3866635..3866976 | + | 342 | WP_000854680.1 | type IV toxin-antitoxin system toxin YkfI | Toxin |
| J6O12_RS18900 (3867797) | 3867797..3869263 | - | 1467 | WP_000723924.1 | hypothetical protein | - |
| J6O12_RS18905 (3869579) | 3869579..3869968 | - | 390 | WP_223596848.1 | hypothetical protein | - |
| J6O12_RS18910 (3870212) | 3870212..3870298 | - | 87 | Protein_3712 | capsid protein | - |
| J6O12_RS18915 (3870503) | 3870503..3871276 | + | 774 | WP_000355484.1 | hypothetical protein | - |
| J6O12_RS18920 (3871337) | 3871337..3871891 | - | 555 | WP_000905043.1 | site-specific DNA recombinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3843359..3879714 | 36355 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12892.95 Da Isoelectric Point: 9.6543
>T213257 WP_000854680.1 NZ_CP081724:3866635-3866976 [Escherichia coli]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
Download Length: 342 bp
>T213257 NZ_CP107503:c5383797-5383414 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11982.62 Da Isoelectric Point: 7.0270
>AT213257 WP_000070396.1 NZ_CP081724:3866297-3866614 [Escherichia coli]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
Download Length: 318 bp
>AT213257 NZ_CP107503:c5384039-5383797 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|