Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2631348..2631986 Replicon chromosome
Accession NZ_CP081724
Organism Escherichia coli strain CX07

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag J6O12_RS12855 Protein ID WP_000813794.1
Coordinates 2631810..2631986 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J6O12_RS12850 Protein ID WP_001270286.1
Coordinates 2631348..2631764 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O12_RS12830 (2626500) 2626500..2627441 - 942 WP_001251313.1 ABC transporter permease -
J6O12_RS12835 (2627442) 2627442..2628455 - 1014 WP_000220434.1 ABC transporter ATP-binding protein -
J6O12_RS12840 (2628473) 2628473..2629618 - 1146 WP_000047430.1 ABC transporter substrate-binding protein -
J6O12_RS12845 (2629863) 2629863..2631269 - 1407 WP_000760630.1 PLP-dependent aminotransferase family protein -
J6O12_RS12850 (2631348) 2631348..2631764 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
J6O12_RS12855 (2631810) 2631810..2631986 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
J6O12_RS12860 (2632208) 2632208..2632438 + 231 WP_000494244.1 YncJ family protein -
J6O12_RS12865 (2632530) 2632530..2634491 - 1962 WP_001488038.1 23S rRNA 5-hydroxycytidine C2501 synthase -
J6O12_RS12870 (2634564) 2634564..2635100 - 537 WP_000429169.1 DNA-binding transcriptional regulator SutR -
J6O12_RS12875 (2635192) 2635192..2636367 + 1176 WP_001236305.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T213255 WP_000813794.1 NZ_CP081724:c2631986-2631810 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T213255 NZ_CP107503:c4903429-4903145 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT213255 WP_001270286.1 NZ_CP081724:c2631764-2631348 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT213255 NZ_CP107503:c4903661-4903419 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References