Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 928354..929008 Replicon chromosome
Accession NZ_CP081724
Organism Escherichia coli strain CX07

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag J6O12_RS04625 Protein ID WP_000244781.1
Coordinates 928601..929008 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag J6O12_RS04620 Protein ID WP_000354046.1
Coordinates 928354..928620 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O12_RS04595 (923519) 923519..924261 + 743 Protein_903 SDR family oxidoreductase -
J6O12_RS04600 (924323) 924323..925756 - 1434 WP_001389468.1 6-phospho-beta-glucosidase BglA -
J6O12_RS04605 (925801) 925801..926112 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
J6O12_RS04610 (926276) 926276..926935 + 660 WP_000250274.1 hemolysin III family protein -
J6O12_RS04615 (927131) 927131..928111 - 981 WP_000886082.1 tRNA-modifying protein YgfZ -
J6O12_RS04620 (928354) 928354..928620 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
J6O12_RS04625 (928601) 928601..929008 + 408 WP_000244781.1 protein YgfX Toxin
J6O12_RS04630 (929048) 929048..929569 - 522 WP_001055868.1 flavodoxin FldB -
J6O12_RS04635 (929681) 929681..930577 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
J6O12_RS04640 (930602) 930602..931312 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
J6O12_RS04645 (931318) 931318..933051 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T213242 WP_000244781.1 NZ_CP081724:928601-929008 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T213242 NZ_CP107499:c125828-125412 [Klebsiella pneumoniae]
ATGACCAAAACCTACATGCTGGATACTAATATCTGCTCTTATATCATGCGCGAACAACCGGAAGCGGTGCTGAAACGCCT
AGAGCAAGCGGTGTTGCGCCGTCACCGGATAGTGGTGTCAGCCATCACCTATGCCGAAATGCGTTTTGGTGCCATCGGTA
AAAGGGCTTCGCCCCGTCATGTGCAGCTGGTGGACGCATTCTGTGCGCGCCTTGATGCCATACTGGCTTGGGATCGGGCC
GCAGTTGACGCTACAACAGAGGTTAAGGCCACGCTAGCAGCTGCCGGCACGCCAATCGGCCCAAACGACACAGCCATTGC
TGGACATGCCATTGCCGCTGGCGCCATCCTGGTGACGAATAATACGCGTGAATTTGAGCGAGTCGCTGGTCTGACGTTTG
AAGACTGGGTGCAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT213242 WP_000354046.1 NZ_CP081724:928354-928620 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT213242 NZ_CP107499:c126055-125825 [Klebsiella pneumoniae]
ATGCGAACTGTATCTGTATTCAGGAACGGTAATAACCGGGCCATCCGTCTGCCCCGCGATCTGGACTTTGACGGCGTGAA
CGAACTGGAAATCATCCGCGAGGGCGATACCCTCATCCTGCGGCCGGTAAAACCCAGTTGGAGTTCGTTCCGCCAGGAGG
AAAAAGCTGACGCAGATTTTATGGCGGAGCGTGAAAATGTTGTTAGTGACGAGGGACGTTTTGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References