Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 41010..41535 Replicon plasmid unnamed2
Accession NZ_CP081721
Organism Escherichia coli strain CX05

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag J6O38_RS25220 Protein ID WP_016240353.1
Coordinates 41230..41535 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A8H9ZZC6
Locus tag J6O38_RS25215 Protein ID WP_016240352.1
Coordinates 41010..41228 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O38_RS25195 (J6O38_25105) 38299..39399 + 1101 WP_032192045.1 NADH:flavin oxidoreductase/NADH oxidase -
J6O38_RS25200 (J6O38_25110) 39480..39731 - 252 WP_105966327.1 hypothetical protein -
J6O38_RS25205 (J6O38_25115) 39767..40183 - 417 WP_032192044.1 type II toxin-antitoxin system VapC family toxin -
J6O38_RS25210 (J6O38_25120) 40180..40410 - 231 WP_001261283.1 type II toxin-antitoxin system VapB family antitoxin -
J6O38_RS25215 (J6O38_25125) 41010..41228 + 219 WP_016240352.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
J6O38_RS25220 (J6O38_25130) 41230..41535 + 306 WP_016240353.1 type II toxin-antitoxin system toxin CcdB Toxin
J6O38_RS25225 (J6O38_25135) 41705..42720 + 1016 Protein_56 hypothetical protein -
J6O38_RS25230 (J6O38_25140) 42918..43712 + 795 WP_016240356.1 site-specific integrase -
J6O38_RS25240 (J6O38_25150) 44589..45140 - 552 WP_223610888.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..94675 94675


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11518.20 Da        Isoelectric Point: 5.6752

>T213236 WP_016240353.1 NZ_CP081721:41230-41535 [Escherichia coli]
MQFKVYAYKRESCYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRDLYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T213236 NZ_CP107498:3029710-3030078 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8321.25 Da        Isoelectric Point: 4.5358

>AT213236 WP_016240352.1 NZ_CP081721:41010-41228 [Escherichia coli]
MKQRITVTIDSDSYQLLKSADVNISGLVNTAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFAEENRDW

Download         Length: 219 bp

>AT213236 NZ_CP107498:3029492-3029713 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References