Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 39767..40410 | Replicon | plasmid unnamed2 |
Accession | NZ_CP081721 | ||
Organism | Escherichia coli strain CX05 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | A0A6N9SI53 |
Locus tag | J6O38_RS25205 | Protein ID | WP_032192044.1 |
Coordinates | 39767..40183 (-) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | H9AC95 |
Locus tag | J6O38_RS25210 | Protein ID | WP_001261283.1 |
Coordinates | 40180..40410 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
J6O38_RS25190 (J6O38_25100) | 35634..36977 | + | 1344 | WP_032192047.1 | APC family permease | - |
J6O38_RS25195 (J6O38_25105) | 38299..39399 | + | 1101 | WP_032192045.1 | NADH:flavin oxidoreductase/NADH oxidase | - |
J6O38_RS25200 (J6O38_25110) | 39480..39731 | - | 252 | WP_105966327.1 | hypothetical protein | - |
J6O38_RS25205 (J6O38_25115) | 39767..40183 | - | 417 | WP_032192044.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
J6O38_RS25210 (J6O38_25120) | 40180..40410 | - | 231 | WP_001261283.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
J6O38_RS25215 (J6O38_25125) | 41010..41228 | + | 219 | WP_016240352.1 | type II toxin-antitoxin system antitoxin CcdA | - |
J6O38_RS25220 (J6O38_25130) | 41230..41535 | + | 306 | WP_016240353.1 | type II toxin-antitoxin system toxin CcdB | - |
J6O38_RS25225 (J6O38_25135) | 41705..42720 | + | 1016 | Protein_56 | hypothetical protein | - |
J6O38_RS25230 (J6O38_25140) | 42918..43712 | + | 795 | WP_016240356.1 | site-specific integrase | - |
J6O38_RS25240 (J6O38_25150) | 44589..45140 | - | 552 | WP_223610888.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | - | - | 1..94675 | 94675 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15113.64 Da Isoelectric Point: 7.7809
>T213235 WP_032192044.1 NZ_CP081721:c40183-39767 [Escherichia coli]
MKKTYMLDTCICSFIMREQPEAVLTRLEQAVLRGHRIVISAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATIEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVK
MKKTYMLDTCICSFIMREQPEAVLTRLEQAVLRGHRIVISAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATIEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVK
Download Length: 417 bp
>T213235 NZ_CP107498:c2624149-2623766 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8737.83 Da Isoelectric Point: 4.3775
>AT213235 WP_001261283.1 NZ_CP081721:c40410-40180 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRFEL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRFEL
Download Length: 231 bp
>AT213235 NZ_CP107498:c2624391-2624149 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6N9SI53 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6X6R7C5 |