Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 4114374..4114924 | Replicon | chromosome |
Accession | NZ_CP081719 | ||
Organism | Escherichia coli strain CX05 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | D7Y6T6 |
Locus tag | J6O38_RS20155 | Protein ID | WP_001160971.1 |
Coordinates | 4114374..4114688 (-) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | V0VEX8 |
Locus tag | J6O38_RS20160 | Protein ID | WP_000125566.1 |
Coordinates | 4114691..4114924 (-) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
J6O38_RS20130 (4110049) | 4110049..4111335 | + | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
J6O38_RS20135 (4111335) | 4111335..4112324 | + | 990 | WP_000241253.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
J6O38_RS20140 (4112321) | 4112321..4113142 | + | 822 | WP_001065392.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
J6O38_RS20145 (4113145) | 4113145..4113522 | + | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
J6O38_RS20150 (4113529) | 4113529..4114377 | + | 849 | WP_000257189.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
J6O38_RS20155 (4114374) | 4114374..4114688 | - | 315 | WP_001160971.1 | CcdB family protein | Toxin |
J6O38_RS20160 (4114691) | 4114691..4114924 | - | 234 | WP_000125566.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
J6O38_RS20165 (4115010) | 4115010..4115489 | - | 480 | WP_001487721.1 | type 3 dihydrofolate reductase | - |
J6O38_RS20170 (4115681) | 4115681..4117543 | - | 1863 | WP_223610817.1 | glutathione-regulated potassium-efflux system protein KefC | - |
J6O38_RS20175 (4117536) | 4117536..4118066 | - | 531 | WP_000600718.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
J6O38_RS20180 (4118177) | 4118177..4119508 | - | 1332 | WP_001183198.1 | MFS transporter | - |
J6O38_RS20185 (4119566) | 4119566..4119853 | - | 288 | WP_000203741.1 | ferredoxin-like protein FixX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11741.75 Da Isoelectric Point: 9.0851
>T213227 WP_001160971.1 NZ_CP081719:c4114688-4114374 [Escherichia coli]
MQFTVYRSRSRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
MQFTVYRSRSRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
Download Length: 315 bp
>T213227 NZ_CP107495:c78398-78249 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8530.53 Da Isoelectric Point: 5.8062
>AT213227 WP_000125566.1 NZ_CP081719:c4114924-4114691 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
Download Length: 234 bp
>AT213227 NZ_CP107495:78443-78502 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A241QVQ9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LTM9 |