Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3667639..3668257 Replicon chromosome
Accession NZ_CP081719
Organism Escherichia coli strain CX05

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag J6O38_RS17905 Protein ID WP_001291435.1
Coordinates 3668039..3668257 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag J6O38_RS17900 Protein ID WP_000344800.1
Coordinates 3667639..3668013 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O38_RS17890 (3662728) 3662728..3663921 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
J6O38_RS17895 (3663944) 3663944..3667093 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
J6O38_RS17900 (3667639) 3667639..3668013 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
J6O38_RS17905 (3668039) 3668039..3668257 + 219 WP_001291435.1 HHA domain-containing protein Toxin
J6O38_RS17910 (3668429) 3668429..3668980 + 552 WP_000102564.1 maltose O-acetyltransferase -
J6O38_RS17915 (3669096) 3669096..3669566 + 471 WP_000136192.1 YlaC family protein -
J6O38_RS17920 (3669730) 3669730..3671280 + 1551 WP_001514985.1 cyclic-guanylate-specific phosphodiesterase PdeB -
J6O38_RS17925 (3671322) 3671322..3671675 - 354 WP_000878140.1 DUF1428 domain-containing protein -
J6O38_RS17935 (3672054) 3672054..3672365 + 312 WP_000409911.1 MGMT family protein -
J6O38_RS17940 (3672396) 3672396..3672968 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T213225 WP_001291435.1 NZ_CP081719:3668039-3668257 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T213225 NZ_CP107494:c125827-125411 [Klebsiella pneumoniae]
ATGACCAAAACCTACATGCTGGATACTAATATCTGCTCTTATATCATGCGCGAACAACCGGAAGCGGTGCTGAAACGCCT
AGAGCAAGCGGTGTTGCGCCGTCACCGGATAGTGGTGTCAGCCATCACCTATGCCGAAATGCGTTTTGGTGCCATCGGTA
AAAGGGCTTCGCCCCGTCATGTGCAGCTGGTGGACGCATTCTGTGCGCGCCTTGATGCCATACTGGCTTGGGATCGGGCC
GCAGTTGACGCTACAACAGAGGTTAAGGCCACGCTAGCAGCTGCCGGCACGCCAATCGGCCCAAACGACACAGCCATTGC
TGGACATGCCATTGCCGCTGGCGCCATCCTGGTGACGAATAATACGCGTGAATTTGAGCGAGTCGCTGGTCTGACGTTTG
AAGACTGGGTGCAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT213225 WP_000344800.1 NZ_CP081719:3667639-3668013 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT213225 NZ_CP107494:c126054-125824 [Klebsiella pneumoniae]
ATGCGAACTGTATCTGTATTCAGGAACGGTAATAACCGGGCCATCCGTCTGCCCCGCGATCTGGACTTTGACGGCGTGAA
CGAACTGGAAATCATCCGCGAGGGCGATACCCTCATCCTGCGGCCGGTAAAACCCAGTTGGAGTTCGTTCCGCCAGGAGG
AAAAAGCTGACGCAGATTTTATGGCGGAGCGTGAAAATGTTGTTAGTGACGAGGGACGTTTTGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References