Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 39751..40276 Replicon plasmid unnamed2
Accession NZ_CP081715
Organism Escherichia coli strain CX04

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag J6O07_RS25180 Protein ID WP_016240353.1
Coordinates 39751..40056 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A8H9ZZC6
Locus tag J6O07_RS25185 Protein ID WP_016240352.1
Coordinates 40058..40276 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O07_RS25160 (J6O07_25070) 36146..36697 + 552 WP_223610888.1 hypothetical protein -
J6O07_RS25165 (J6O07_25075) 36731..37428 + 698 WP_223610889.1 IS1 family transposase -
J6O07_RS25170 (J6O07_25080) 37574..38368 - 795 WP_016240356.1 site-specific integrase -
J6O07_RS25175 (J6O07_25085) 38566..39581 - 1016 Protein_48 hypothetical protein -
J6O07_RS25180 (J6O07_25090) 39751..40056 - 306 WP_016240353.1 type II toxin-antitoxin system toxin CcdB Toxin
J6O07_RS25185 (J6O07_25095) 40058..40276 - 219 WP_016240352.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
J6O07_RS25190 (J6O07_25100) 40876..41106 + 231 WP_001261283.1 type II toxin-antitoxin system VapB family antitoxin -
J6O07_RS25195 (J6O07_25105) 41103..41519 + 417 WP_032192044.1 type II toxin-antitoxin system VapC family toxin -
J6O07_RS25200 (J6O07_25110) 41555..41806 + 252 WP_105966327.1 hypothetical protein -
J6O07_RS25205 (J6O07_25115) 41887..42987 - 1101 WP_032192045.1 NADH:flavin oxidoreductase/NADH oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..94674 94674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11518.20 Da        Isoelectric Point: 5.6752

>T213203 WP_016240353.1 NZ_CP081715:c40056-39751 [Escherichia coli]
MQFKVYAYKRESCYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRDLYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T213203 NZ_CP107488:3059772-3060140 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8321.25 Da        Isoelectric Point: 4.5358

>AT213203 WP_016240352.1 NZ_CP081715:c40276-40058 [Escherichia coli]
MKQRITVTIDSDSYQLLKSADVNISGLVNTAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFAEENRDW

Download         Length: 219 bp

>AT213203 NZ_CP107488:3059554-3059775 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References