Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeV-yafW/CbtA-CbeA |
| Location | 4424123..4424916 | Replicon | chromosome |
| Accession | NZ_CP081713 | ||
| Organism | Escherichia coli strain CX04 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1EZ92 |
| Locus tag | J6O07_RS21710 | Protein ID | WP_000854726.1 |
| Coordinates | 4424539..4424916 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | S1EBQ7 |
| Locus tag | J6O07_RS21705 | Protein ID | WP_001548930.1 |
| Coordinates | 4424123..4424449 (+) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J6O07_RS21660 (4419561) | 4419561..4420382 | + | 822 | WP_223610821.1 | DUF932 domain-containing protein | - |
| J6O07_RS21665 (4420599) | 4420599..4421300 | + | 702 | WP_016239437.1 | WYL domain-containing protein | - |
| J6O07_RS21670 (4421341) | 4421341..4421577 | + | 237 | WP_001144031.1 | protein YpjK | - |
| J6O07_RS21675 (4421577) | 4421577..4422020 | + | 444 | WP_001547764.1 | lipoprotein YafY | - |
| J6O07_RS21680 (4422043) | 4422043..4422510 | + | 468 | WP_001385283.1 | protein YkfB | - |
| J6O07_RS21685 (4422587) | 4422587..4422826 | + | 240 | WP_000194654.1 | DUF905 family protein | - |
| J6O07_RS21690 (4422924) | 4422924..4423382 | + | 459 | WP_000211838.1 | antirestriction protein | - |
| J6O07_RS21695 (4423398) | 4423398..4423874 | + | 477 | WP_000811693.1 | RadC family protein | - |
| J6O07_RS21700 (4423883) | 4423883..4424104 | + | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
| J6O07_RS21705 (4424123) | 4424123..4424449 | + | 327 | WP_001548930.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
| J6O07_RS21710 (4424539) | 4424539..4424916 | + | 378 | WP_000854726.1 | TA system toxin CbtA family protein | Toxin |
| J6O07_RS21715 (4424913) | 4424913..4425401 | + | 489 | WP_001547769.1 | DUF5983 family protein | - |
| J6O07_RS21720 (4425413) | 4425413..4425610 | + | 198 | WP_000839269.1 | DUF957 domain-containing protein | - |
| J6O07_RS21725 (4425695) | 4425695..4426537 | + | 843 | WP_001547770.1 | DUF4942 domain-containing protein | - |
| J6O07_RS21730 (4427286) | 4427286..4428824 | + | 1539 | WP_001187177.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4409832..4436637 | 26805 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14164.10 Da Isoelectric Point: 7.8045
>T213199 WP_000854726.1 NZ_CP081713:4424539-4424916 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T213199 NZ_CP107488:c2071511-2070978 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12301.97 Da Isoelectric Point: 7.0273
>AT213199 WP_001548930.1 NZ_CP081713:4424123-4424449 [Escherichia coli]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK
Download Length: 327 bp
>AT213199 NZ_CP107488:c2071788-2071522 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|