Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3667631..3668249 Replicon chromosome
Accession NZ_CP081713
Organism Escherichia coli strain CX04

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag J6O07_RS17895 Protein ID WP_001291435.1
Coordinates 3668031..3668249 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag J6O07_RS17890 Protein ID WP_000344800.1
Coordinates 3667631..3668005 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O07_RS17880 (3662720) 3662720..3663913 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
J6O07_RS17885 (3663936) 3663936..3667085 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
J6O07_RS17890 (3667631) 3667631..3668005 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
J6O07_RS17895 (3668031) 3668031..3668249 + 219 WP_001291435.1 HHA domain-containing protein Toxin
J6O07_RS17900 (3668421) 3668421..3668972 + 552 WP_000102564.1 maltose O-acetyltransferase -
J6O07_RS17905 (3669088) 3669088..3669558 + 471 WP_000136192.1 YlaC family protein -
J6O07_RS17910 (3669722) 3669722..3671272 + 1551 WP_001514985.1 cyclic-guanylate-specific phosphodiesterase PdeB -
J6O07_RS17915 (3671314) 3671314..3671667 - 354 WP_000878140.1 DUF1428 domain-containing protein -
J6O07_RS17925 (3672046) 3672046..3672357 + 312 WP_000409911.1 MGMT family protein -
J6O07_RS17930 (3672388) 3672388..3672960 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T213194 WP_001291435.1 NZ_CP081713:3668031-3668249 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T213194 NZ_CP107485:c91481-91065 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT213194 WP_000344800.1 NZ_CP081713:3667631-3668005 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT213194 NZ_CP107485:c91708-91478 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References