Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2631342..2631980 Replicon chromosome
Accession NZ_CP081713
Organism Escherichia coli strain CX04

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag J6O07_RS12850 Protein ID WP_000813794.1
Coordinates 2631804..2631980 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J6O07_RS12845 Protein ID WP_001270286.1
Coordinates 2631342..2631758 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O07_RS12825 (2626494) 2626494..2627435 - 942 WP_001251313.1 ABC transporter permease -
J6O07_RS12830 (2627436) 2627436..2628449 - 1014 WP_000220434.1 ABC transporter ATP-binding protein -
J6O07_RS12835 (2628467) 2628467..2629612 - 1146 WP_000047430.1 ABC transporter substrate-binding protein -
J6O07_RS12840 (2629857) 2629857..2631263 - 1407 WP_000760630.1 PLP-dependent aminotransferase family protein -
J6O07_RS12845 (2631342) 2631342..2631758 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
J6O07_RS12850 (2631804) 2631804..2631980 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
J6O07_RS12855 (2632202) 2632202..2632432 + 231 WP_000494244.1 YncJ family protein -
J6O07_RS12860 (2632524) 2632524..2634485 - 1962 WP_001488038.1 23S rRNA 5-hydroxycytidine C2501 synthase -
J6O07_RS12865 (2634558) 2634558..2635094 - 537 WP_000429169.1 DNA-binding transcriptional regulator SutR -
J6O07_RS12870 (2635186) 2635186..2636361 + 1176 WP_001236305.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T213193 WP_000813794.1 NZ_CP081713:c2631980-2631804 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T213193 NZ_CP107485:c78392-78243 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT213193 WP_001270286.1 NZ_CP081713:c2631758-2631342 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT213193 NZ_CP107485:78437-78496 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References