Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 954026..954824 Replicon chromosome
Accession NC_007606
Organism Shigella dysenteriae Sd197

Toxin (Protein)


Gene name yeeV Uniprot ID Q32HN1
Locus tag SDY_RS04970 Protein ID WP_001094433.1
Coordinates 954026..954400 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q32HN0
Locus tag SDY_RS04975 Protein ID WP_001285603.1
Coordinates 954447..954824 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SDY_RS04935 949611..950165 - 555 WP_001001927.1 molecular chaperone YcdY -
SDY_RS04940 950189..950926 - 738 WP_000283663.1 zinc-binding phosphatase -
SDY_RS04945 950981..951919 - 939 WP_000351336.1 glyoxylate/hydroxypyruvate reductase GhrA -
SDY_RS04955 952390..953232 - 843 WP_005020348.1 DUF4942 domain-containing protein -
SDY_RS04960 953329..953526 - 198 WP_011378633.1 DUF957 domain-containing protein -
SDY_RS04965 953538..954029 - 492 WP_000976859.1 hypothetical protein -
SDY_RS04970 954026..954400 - 375 WP_001094433.1 toxin Toxin
SDY_RS04975 954447..954824 - 378 WP_001285603.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
SDY_RS04980 954874..955518 - 645 WP_000086764.1 hypothetical protein -
SDY_RS04985 955537..955758 - 222 WP_000692331.1 DUF987 domain-containing protein -
SDY_RS04990 955827..956279 - 453 WP_001186198.1 RadC family protein -
SDY_RS04995 956295..956768 - 474 WP_001313575.1 antirestriction protein -
SDY_RS05000 957048..957869 - 822 WP_001234573.1 DUF945 domain-containing protein -
SDY_RS05005 957970..958143 - 174 WP_000088742.1 DUF905 family protein -
SDY_RS05010 958263..958746 - 484 Protein_963 hypothetical protein -
SDY_RS05015 959177..959644 - 468 WP_000668907.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13918.86 Da        Isoelectric Point: 6.8517

>T21318 WP_001094433.1 NC_007606:c954400-954026 [Shigella dysenteriae Sd197]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSPLINSIDILRARRVTGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T21318 NC_007606:c954400-954026 [Shigella dysenteriae Sd197]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCCGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGTGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13789.72 Da        Isoelectric Point: 6.4643

>AT21318 WP_001285603.1 NC_007606:c954824-954447 [Shigella dysenteriae Sd197]
VSDTLPGTTLPDDNKDRPWWRLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT21318 NC_007606:c954824-954447 [Shigella dysenteriae Sd197]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGATAACAAAGACCGCCCCTGGTGGAGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCAGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCTGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCACCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NBY3

Antitoxin

Source ID Structure
AlphaFold DB A0A090NW75

References