Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 836319..836838 Replicon chromosome
Accession NZ_CP081706
Organism Escherichia coli strain AH04

Toxin (Protein)


Gene name parE Uniprot ID A0A837F4A9
Locus tag J6O21_RS04185 Protein ID WP_000277490.1
Coordinates 836554..836838 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A6P1V8C3
Locus tag J6O21_RS04180 Protein ID WP_000124732.1
Coordinates 836319..836561 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O21_RS04165 (832739) 832739..833953 - 1215 WP_005012528.1 type II site-specific deoxyribonuclease -
J6O21_RS04170 (834065) 834065..834769 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
J6O21_RS04175 (834775) 834775..835746 + 972 WP_202195906.1 plasmid replication initiator RepA -
J6O21_RS04180 (836319) 836319..836561 + 243 WP_000124732.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
J6O21_RS04185 (836554) 836554..836838 + 285 WP_000277490.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J6O21_RS04190 (836976) 836976..837068 - 93 Protein_823 plasmid partition protein ParG -
J6O21_RS04195 (837388) 837388..837606 - 219 Protein_824 IS110 family transposase -
J6O21_RS04200 (837607) 837607..837906 - 300 Protein_825 glycogen/starch synthase -
J6O21_RS04205 (837906) 837906..839204 - 1299 WP_053287384.1 glucose-1-phosphate adenylyltransferase -
J6O21_RS04210 (839219) 839219..841195 - 1977 WP_223571364.1 glycogen debranching protein GlgX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-88)

Antitoxin

Antitoxin ParD

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11005.52 Da        Isoelectric Point: 6.2103

>T213129 WP_000277490.1 NZ_CP081706:836554-836838 [Escherichia coli]
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL

Download         Length: 285 bp

>T213129 NZ_CP107468:328021-328389 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8875.01 Da        Isoelectric Point: 7.0130

>AT213129 WP_000124732.1 NZ_CP081706:836319-836561 [Escherichia coli]
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV

Download         Length: 243 bp

>AT213129 NZ_CP107468:327803-328024 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F4A9

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V8C3

References