Detailed information of TA system TA021312

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 1234338..1234848
• Replicon: chromosome
• Accession: NC_007604
• Organism: Synechococcus elongatus PCC 7942

Toxin (Protein)

• Gene name: relB
• Uniprot ID: Q8KPS4
• Locus tag: SYNPCC7942_RS06180
• Protein ID: WP_011242657.1
• Coordinates: 1234338..1234601 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: Q31NY1
• Locus tag: SYNPCC7942_RS06185
• Protein ID: WP_011242656.1
• Coordinates: 1234594..1234848 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SYNPCC7942_RS06155	1230512..1232962	-	2451	WP_011242661.1	glycosyltransferase family 39 protein	-
SYNPCC7942_RS06160	1233050..1233463	-	414	WP_011242660.1	type II toxin-antitoxin system VapC family toxin	-
SYNPCC7942_RS06165	1233460..1233702	-	243	WP_190528567.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
SYNPCC7942_RS06170	1233775..1233939	+	165	WP_011377917.1	tyrosine-type recombinase/integrase	-
SYNPCC7942_RS06175	1233936..1234211	+	276	WP_011242658.1	DUF2281 domain-containing protein	-
SYNPCC7942_RS06180	1234338..1234601	-	264	WP_011242657.1	Txe/YoeB family addiction module toxin	Toxin
SYNPCC7942_RS06185	1234594..1234848	-	255	WP_011242656.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
SYNPCC7942_RS06190	1234970..1235230	-	261	WP_011242655.1	DUF2442 domain-containing protein	-
SYNPCC7942_RS06195	1235233..1235481	-	249	WP_011377918.1	DUF4160 domain-containing protein	-
SYNPCC7942_RS06200	1235481..1235825	-	345	WP_011242653.1	DUF2442 domain-containing protein	-
SYNPCC7942_RS06205	1235830..1236090	-	261	WP_011242652.1	DUF4160 domain-containing protein	-
SYNPCC7942_RS06210	1236242..1236466	+	225	WP_039755738.1	hypothetical protein	-
SYNPCC7942_RS06215	1236470..1236886	+	417	WP_011377919.1	type II toxin-antitoxin system VapC family toxin	-
SYNPCC7942_RS06220	1237038..1237520	+	483	WP_173282542.1	glutathione peroxidase	-
SYNPCC7942_RS06225	1237546..1238553	+	1008	WP_011377920.1	acyl-CoA dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10434.75 Da
• Isoelectric Point: 6.9760

>T21312 WP_011242657.1 NC_007604:c1234601-1234338 [Synechococcus elongatus PCC 7942 = FACHB-805]
MRKLAWTNEAWEDYLYWQGQDKKTLNRINKLITETLRSPFEGIGKPEALRENLTGFWSRRIDDTNRLVYAVADDYLTIIS
CRYHYSD

Nucleotide

• Length: 264 bp

>T21312 NC_007604:c1234601-1234338 [Synechococcus elongatus PCC 7942 = FACHB-805]
ATGCGTAAGCTGGCTTGGACAAACGAGGCTTGGGAAGATTACCTGTATTGGCAAGGGCAGGACAAGAAGACCTTAAATCG
CATCAACAAGCTCATTACCGAAACCTTGCGATCGCCCTTTGAGGGGATTGGTAAGCCAGAAGCGCTCAGGGAGAACCTGA
CTGGGTTTTGGTCACGCCGCATTGACGACACCAATCGCTTAGTTTACGCAGTAGCAGATGACTACCTGACCATTATTTCC
TGTCGCTACCACTACAGCGATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9478.72 Da
• Isoelectric Point: 5.6400

>AT21312 WP_011242656.1 NC_007604:c1234848-1234594 [Synechococcus elongatus PCC 7942 = FACHB-805]
MKVVSFSDARKNLKTVLDEVVNDADYTIITRRNAEEVVVMSLDSFNSLIETFHLLKSPANAAHLQRSIAQYQQGQTVERN
LLDA

Nucleotide

• Length: 255 bp

>AT21312 NC_007604:c1234848-1234594 [Synechococcus elongatus PCC 7942 = FACHB-805]
ATGAAAGTTGTTTCCTTCAGTGACGCCAGAAAAAATCTCAAGACTGTCTTGGATGAAGTCGTCAACGACGCTGACTACAC
GATCATTACTCGCCGCAATGCCGAGGAAGTCGTGGTCATGTCCCTCGACTCCTTCAATAGCCTGATCGAAACCTTCCACC
TGCTCAAATCCCCTGCCAATGCTGCTCACCTACAACGCTCGATCGCTCAGTACCAGCAAGGTCAAACAGTCGAGCGAAAT
CTATTAGATGCGTAA

Structures

Toxin

• AlphaFold DB: Q8KPS4

Antitoxin

• AlphaFold DB: Q31NY1