Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3583546..3584164 Replicon chromosome
Accession NZ_CP081701
Organism Escherichia coli strain AH02

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag J6O02_RS17810 Protein ID WP_001291435.1
Coordinates 3583946..3584164 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag J6O02_RS17805 Protein ID WP_000344800.1
Coordinates 3583546..3583920 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O02_RS17795 (3578635) 3578635..3579828 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
J6O02_RS17800 (3579851) 3579851..3583000 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
J6O02_RS17805 (3583546) 3583546..3583920 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
J6O02_RS17810 (3583946) 3583946..3584164 + 219 WP_001291435.1 HHA domain-containing protein Toxin
J6O02_RS17815 (3584336) 3584336..3584887 + 552 WP_000102564.1 maltose O-acetyltransferase -
J6O02_RS17820 (3585003) 3585003..3585473 + 471 WP_000136192.1 YlaC family protein -
J6O02_RS17825 (3585637) 3585637..3587187 + 1551 WP_001514985.1 cyclic-guanylate-specific phosphodiesterase PdeB -
J6O02_RS17830 (3587229) 3587229..3587582 - 354 WP_000878140.1 DUF1428 domain-containing protein -
J6O02_RS17840 (3587961) 3587961..3588272 + 312 WP_000409911.1 MGMT family protein -
J6O02_RS17845 (3588303) 3588303..3588875 - 573 WP_001548252.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T213113 WP_001291435.1 NZ_CP081701:3583946-3584164 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T213113 NZ_CP107462:2792-3058 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT213113 WP_000344800.1 NZ_CP081701:3583546-3583920 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT213113 NZ_CP107462:2584-2808 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References