Detailed information of TA system TA021310

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 2047069..2047525
• Replicon: chromosome
• Accession: NC_007575
• Organism: Sulfurimonas denitrificans DSM 1251

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SUDEN_RS10205
• Protein ID: WP_148153614.1
• Coordinates: 2047283..2047525 (+)
• Length: 81 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: Q30P42
• Locus tag: SUDEN_RS10200
• Protein ID: WP_011373579.1
• Coordinates: 2047069..2047278 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SUDEN_RS10160	2042214..2042456	+	243	WP_011373572.1	DUF2442 domain-containing protein	-
SUDEN_RS10165	2042641..2042946	-	306	WP_041672340.1	type II toxin-antitoxin system RelE/ParE family toxin	-
SUDEN_RS10170	2042946..2043155	-	210	WP_011373573.1	hypothetical protein	-
SUDEN_RS10175	2043371..2043565	+	195	WP_011373574.1	YwbE family protein	-
SUDEN_RS10180	2043600..2044073	-	474	WP_011373575.1	pyridoxamine 5'-phosphate oxidase family protein	-
SUDEN_RS10185	2044312..2045601	+	1290	WP_011373576.1	sensor domain-containing diguanylate cyclase	-
SUDEN_RS10190	2045687..2046310	-	624	WP_011373577.1	DsbA family protein	-
SUDEN_RS10195	2046524..2047000	+	477	WP_011373578.1	hypothetical protein	-
SUDEN_RS10200	2047069..2047278	+	210	WP_011373579.1	ribbon-helix-helix domain-containing protein	Antitoxin
SUDEN_RS10205	2047283..2047525	+	243	WP_148153614.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SUDEN_RS10210	2047708..2050506	-	2799	WP_011373581.1	helicase	-
SUDEN_RS10215	2050536..2051705	-	1170	WP_011373582.1	nucleotide sugar dehydrogenase	-
SUDEN_RS10220	2051833..2052276	+	444	WP_011373583.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-79)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 81 a.a.
• Molecular weight: 9563.39 Da
• Isoelectric Point: 9.8472

>T21310 WP_148153614.1 NC_007575:2047283-2047525 [Sulfurimonas denitrificans DSM 1251]
MIDDKVIKDLKQIDKLWQKKIIEVIKTKLVENPHLGKPLVGNLSPYYRLRVFDYRVIYEINDDEVVVIVIKIGHRKDIYK

Nucleotide

• Length: 243 bp

>T21310 NC_007575:2047283-2047525 [Sulfurimonas denitrificans DSM 1251]
TTGATTGATGACAAAGTCATTAAAGATTTAAAACAAATTGATAAGTTGTGGCAAAAGAAAATTATAGAAGTCATTAAAAC
AAAGCTTGTAGAAAATCCACATCTTGGGAAACCTCTCGTAGGTAATCTCTCCCCTTATTATCGTTTACGAGTTTTTGATT
ACAGGGTTATTTATGAAATAAATGATGATGAAGTAGTTGTAATTGTCATTAAAATTGGGCATCGTAAAGATATTTATAAA
TAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8180.27 Da
• Isoelectric Point: 4.4764

>AT21310 WP_011373579.1 NC_007575:2047069-2047278 [Sulfurimonas denitrificans DSM 1251]
MLSIRLENSMEAQLNALAEATKRPKSFFVKEALRNYLDDMQEYYEVQKRSNAEDRNLITLEELERALEL

Nucleotide

• Length: 210 bp

>AT21310 NC_007575:2047069-2047278 [Sulfurimonas denitrificans DSM 1251]
ATGCTTTCAATACGACTTGAAAATAGCATGGAAGCGCAGTTAAATGCACTTGCAGAAGCAACAAAACGACCAAAGAGTTT
TTTTGTTAAAGAGGCTTTGAGAAACTATCTTGATGATATGCAGGAGTATTATGAAGTGCAAAAACGCTCAAACGCAGAGG
ATAGAAACCTTATAACACTTGAGGAGCTAGAGAGAGCGCTTGAGTTATAA

Structures

Antitoxin

• AlphaFold DB: Q30P42