Detailed information of TA system TA021309

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 1799685..1800162
• Replicon: chromosome
• Accession: NC_007575
• Organism: Sulfurimonas denitrificans DSM 1251

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: SUDEN_RS08940
• Protein ID: WP_041672558.1
• Coordinates: 1799685..1799948 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q30PT8
• Locus tag: SUDEN_RS08945
• Protein ID: WP_011373334.1
• Coordinates: 1799935..1800162 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SUDEN_RS08925	1795188..1795511	+	324	WP_011373330.1	hypothetical protein	-
SUDEN_RS08930	1795527..1796057	-	531	WP_041672304.1	hypothetical protein	-
SUDEN_RS08935	1796234..1799023	-	2790	WP_011373332.1	hypothetical protein	-
SUDEN_RS08940	1799685..1799948	+	264	WP_041672558.1	BrnT family toxin	Toxin
SUDEN_RS08945	1799935..1800162	+	228	WP_011373334.1	CopG family transcriptional regulator	Antitoxin
SUDEN_RS08950	1800407..1800619	+	213	WP_011373335.1	hypothetical protein	-
SUDEN_RS08955	1800609..1801016	+	408	WP_011373336.1	PIN domain-containing protein	-
SUDEN_RS08960	1801450..1801647	+	198	WP_041672305.1	hypothetical protein	-
SUDEN_RS08965	1801644..1802003	+	360	WP_011373337.1	type II toxin-antitoxin system RelE/ParE family toxin	-
SUDEN_RS08970	1802050..1802604	-	555	WP_011373338.1	recombinase family protein	-
SUDEN_RS08975	1802601..1803203	-	603	WP_011373339.1	site-specific integrase	-
SUDEN_RS08980	1803691..1804437	-	747	WP_011373340.1	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1794231..1795070	839

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-80)

Antitoxin

• CopG antitoxin (2-69)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10372.90 Da
• Isoelectric Point: 9.3522

>T21309 WP_041672558.1 NC_007575:1799685-1799948 [Sulfurimonas denitrificans DSM 1251]
MKFEYYSNKSDINKEKHGIDFEKAKVLWEDDNLLEVPLPFKEEVRHLCIGKILNKHYSAVITYRSKAIRIISVRRSRKEE
INGYENS

Nucleotide

• Length: 264 bp

>T21309 NC_007575:1799685-1799948 [Sulfurimonas denitrificans DSM 1251]
ATGAAATTTGAATATTATAGCAACAAATCAGATATTAATAAAGAGAAGCATGGTATAGACTTTGAGAAAGCTAAAGTGTT
ATGGGAAGATGATAACCTTTTAGAAGTTCCTCTACCTTTTAAAGAGGAAGTACGCCATTTATGCATAGGTAAAATTTTGA
ATAAACATTATTCTGCTGTAATTACATATCGAAGTAAAGCTATTCGTATTATATCTGTTAGAAGATCGAGAAAAGAGGAG
ATAAACGGCTATGAAAACAGTTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8726.19 Da
• Isoelectric Point: 7.0133

>AT21309 WP_011373334.1 NC_007575:1799935-1800162 [Sulfurimonas denitrificans DSM 1251]
MKTVKEFDELFDSGEDISEFVDYSKATRPNLAQKRVNLDLPVWMIEKLDKEAKRLGVARQAIMKMFLAQHLEKAI

Nucleotide

• Length: 228 bp

>AT21309 NC_007575:1799935-1800162 [Sulfurimonas denitrificans DSM 1251]
ATGAAAACAGTTAAAGAGTTTGATGAGCTATTTGATAGTGGTGAAGATATATCAGAGTTTGTTGATTACTCAAAAGCGAC
TAGACCAAATCTTGCCCAAAAGAGAGTTAATCTTGACTTACCAGTATGGATGATTGAAAAACTTGATAAGGAAGCAAAAC
GCTTGGGTGTTGCTAGACAAGCTATTATGAAAATGTTCTTAGCACAACATTTAGAAAAAGCAATATAA

Structures

Antitoxin

• AlphaFold DB: Q30PT8