Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 122948..123473 Replicon plasmid unnamed1
Accession NZ_CP081699
Organism Escherichia coli strain CT02

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag J6N91_RS23800 Protein ID WP_016240353.1
Coordinates 123168..123473 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A8H9ZZC6
Locus tag J6N91_RS23795 Protein ID WP_016240352.1
Coordinates 122948..123166 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6N91_RS23775 (J6N91_23700) 120237..121337 + 1101 WP_032192045.1 NADH:flavin oxidoreductase/NADH oxidase -
J6N91_RS23780 (J6N91_23705) 121418..121669 - 252 WP_105966327.1 hypothetical protein -
J6N91_RS23785 (J6N91_23710) 121705..122121 - 417 WP_032192044.1 type II toxin-antitoxin system VapC family toxin -
J6N91_RS23790 (J6N91_23715) 122118..122348 - 231 WP_001261283.1 type II toxin-antitoxin system VapB family antitoxin -
J6N91_RS23795 (J6N91_23720) 122948..123166 + 219 WP_016240352.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
J6N91_RS23800 (J6N91_23725) 123168..123473 + 306 WP_016240353.1 type II toxin-antitoxin system toxin CcdB Toxin
J6N91_RS23805 (J6N91_23730) 123643..123954 + 312 WP_063615098.1 hypothetical protein -
J6N91_RS23810 (J6N91_23735) 124193..124546 + 354 WP_001114073.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
J6N91_RS23815 (J6N91_23740) 124594..124956 + 363 WP_000783215.1 arsenite efflux transporter metallochaperone ArsD -
J6N91_RS23820 (J6N91_23745) 124974..126725 + 1752 WP_223602145.1 arsenite efflux transporter ATPase subunit ArsA -
J6N91_RS23825 (J6N91_23750) 126774..128063 + 1290 WP_003026002.1 arsenite efflux transporter membrane subunit ArsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..145356 145356


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11518.20 Da        Isoelectric Point: 5.6752

>T213086 WP_016240353.1 NZ_CP081699:123168-123473 [Escherichia coli]
MQFKVYAYKRESCYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRDLYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T213086 NZ_CP107452:c2665952-2665569 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8321.25 Da        Isoelectric Point: 4.5358

>AT213086 WP_016240352.1 NZ_CP081699:122948-123166 [Escherichia coli]
MKQRITVTIDSDSYQLLKSADVNISGLVNTAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFAEENRDW

Download         Length: 219 bp

>AT213086 NZ_CP107452:c2666194-2665952 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References