Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 87914..88515 Replicon plasmid unnamed1
Accession NZ_CP081699
Organism Escherichia coli strain CT02

Toxin (Protein)


Gene name doc Uniprot ID Q47172
Locus tag J6N91_RS23600 Protein ID WP_001694510.1
Coordinates 87914..88294 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag J6N91_RS23605 Protein ID WP_001190712.1
Coordinates 88294..88515 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6N91_RS23565 (J6N91_23495) 83242..83939 + 698 WP_094106546.1 IS1 family transposase -
J6N91_RS23570 (J6N91_23500) 84034..84471 + 438 WP_024195570.1 GyrI-like domain-containing protein -
J6N91_RS23575 84712..85215 - 504 WP_063615128.1 hypothetical protein -
J6N91_RS23580 (J6N91_23510) 85731..85940 + 210 WP_021553350.1 helix-turn-helix domain-containing protein -
J6N91_RS23590 (J6N91_23520) 86785..87702 - 918 Protein_100 DUF968 domain-containing protein -
J6N91_RS23595 (J6N91_23525) 87730..87909 - 180 WP_009446826.1 hypothetical protein -
J6N91_RS23600 (J6N91_23530) 87914..88294 - 381 WP_001694510.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
J6N91_RS23605 (J6N91_23535) 88294..88515 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J6N91_RS23610 (J6N91_23540) 88698..90254 + 1557 WP_047651705.1 type I restriction-modification system subunit M -
J6N91_RS23615 (J6N91_23545) 90251..91453 + 1203 WP_047651693.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..145356 145356


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13616.35 Da        Isoelectric Point: 5.1514

>T213084 WP_001694510.1 NZ_CP081699:c88294-87914 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVVYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T213084 NZ_CP107452:c2186637-2186353 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT213084 WP_001190712.1 NZ_CP081699:c88515-88294 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT213084 NZ_CP107452:c2186869-2186627 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A737M8C8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References