Detailed information of TA system TA021306

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 507441..508041
• Replicon: chromosome
• Accession: NC_007519
• Organism: Desulfovibrio alaskensis G20

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DDE_RS02235
• Protein ID: WP_041277020.1
• Coordinates: 507736..508041 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q315U5
• Locus tag: DDE_RS02230
• Protein ID: WP_011366622.1
• Coordinates: 507441..507743 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DDE_RS02210	503493..504221	+	729	WP_011366618.1	ferrous iron transport protein A	-
DDE_RS02215	504283..504671	+	389	Protein_414	transcriptional repressor	-
DDE_RS02220	504674..506776	+	2103	WP_011366620.1	heavy metal translocating P-type ATPase	-
DDE_RS02225	506850..507098	-	249	WP_011366621.1	hypothetical protein	-
DDE_RS02230	507441..507743	-	303	WP_011366622.1	putative addiction module antidote protein	Antitoxin
DDE_RS02235	507736..508041	-	306	WP_041277020.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DDE_RS02240	508581..510404	-	1824	WP_011366624.1	glutamine--fructose-6-phosphate transaminase (isomerizing)	-
DDE_RS02245	510509..511021	-	513	WP_041277021.1	HPP family protein	-
DDE_RS02250	511225..511854	-	630	WP_011366626.1	XTP/dITP diphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-89)

Antitoxin

• Uncharacterized protein HI1420 (7-92)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11264.78 Da
• Isoelectric Point: 9.8906

>T21306 WP_041277020.1 NC_007519:c508041-507736 [Desulfovibrio alaskensis G20]
MNHFDRTEHFDRWLSKLKDVQGKAKILVRIRSAEKGNFGDCESVGEGVSEMRIHTGPGYRVYFTRRGNTVYLLLAGGDKS
TQKRDIALAKALAAELGGSHE

Nucleotide

• Length: 306 bp

>T21306 NC_007519:c508041-507736 [Desulfovibrio alaskensis G20]
ATGAATCACTTCGACCGTACAGAGCATTTTGACCGTTGGCTTTCAAAGCTGAAGGATGTTCAGGGTAAGGCTAAAATCCT
TGTACGGATACGGTCTGCGGAAAAAGGCAATTTTGGCGATTGCGAGTCCGTAGGGGAAGGTGTTTCTGAAATGCGTATTC
ACACTGGGCCGGGCTACAGGGTGTATTTTACACGGCGTGGCAACACCGTTTACCTTCTGCTTGCAGGTGGTGATAAATCA
ACGCAAAAACGCGACATTGCTCTTGCTAAAGCATTAGCCGCCGAACTGGGAGGTAGTCATGAGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10847.63 Da
• Isoelectric Point: 7.0095

>AT21306 WP_011366622.1 NC_007519:c507743-507441 [Desulfovibrio alaskensis G20]
MSKKIVTRFDAADYLDSEEAMVAYLNAAMEEDDPDILLAAMADVAKAVGMSKLAKDAGIGRESLYKALKPGAQPRYQTIH
KVMNALGMTLQAKPRSAVMQ

Nucleotide

• Length: 303 bp

>AT21306 NC_007519:c507743-507441 [Desulfovibrio alaskensis G20]
ATGAGTAAAAAAATAGTAACCAGATTTGATGCTGCTGACTATCTGGACAGCGAAGAAGCTATGGTTGCCTACCTGAACGC
TGCAATGGAAGAGGATGACCCCGACATTCTTTTGGCTGCCATGGCAGACGTTGCAAAGGCCGTAGGCATGAGCAAGCTGG
CAAAAGACGCCGGCATTGGCCGGGAAAGCCTGTATAAAGCGCTTAAGCCCGGGGCACAACCCAGATACCAGACTATTCAT
AAGGTGATGAATGCGCTGGGCATGACCTTACAGGCAAAGCCCAGATCTGCCGTGATGCAGTAA

Structures

Antitoxin

• AlphaFold DB: Q315U5