Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 27809..28452 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP081691 | ||
| Organism | Escherichia coli strain 0H25 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | - |
| Locus tag | J6O25_RS24610 | Protein ID | WP_088765932.1 |
| Coordinates | 28036..28452 (+) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | D5KTK7 |
| Locus tag | J6O25_RS24605 | Protein ID | WP_001261282.1 |
| Coordinates | 27809..28039 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J6O25_RS24570 (J6O25_24450) | 23231..23671 | - | 441 | Protein_28 | ISNCY family transposase | - |
| J6O25_RS24575 (J6O25_24455) | 23740..24451 | + | 712 | Protein_29 | IS6 family transposase | - |
| J6O25_RS24580 (J6O25_24460) | 24503..24682 | - | 180 | Protein_30 | hypothetical protein | - |
| J6O25_RS24585 (J6O25_24465) | 24768..25940 | + | 1173 | WP_042111630.1 | IS21-like element IS21 family transposase | - |
| J6O25_RS24590 (J6O25_24470) | 25940..26737 | + | 798 | WP_000544830.1 | IS21-like element IS21 family helper ATPase IstB | - |
| J6O25_RS27365 | 26731..26853 | - | 123 | WP_257606738.1 | hypothetical protein | - |
| J6O25_RS24595 (J6O25_24475) | 26897..27247 | - | 351 | WP_000493399.1 | hypothetical protein | - |
| J6O25_RS24600 (J6O25_24480) | 27391..27852 | - | 462 | WP_223584524.1 | hypothetical protein | - |
| J6O25_RS24605 (J6O25_24485) | 27809..28039 | + | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| J6O25_RS24610 (J6O25_24490) | 28036..28452 | + | 417 | WP_088765932.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| J6O25_RS24615 (J6O25_24495) | 28550..28690 | - | 141 | WP_045286941.1 | helix-turn-helix domain-containing protein | - |
| J6O25_RS24620 (J6O25_24500) | 28789..29493 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| J6O25_RS24625 (J6O25_24505) | 29556..30077 | + | 522 | Protein_40 | glucose-1-phosphate adenylyltransferase | - |
| J6O25_RS24630 (J6O25_24510) | 30077..30376 | + | 300 | Protein_41 | glycogen/starch synthase | - |
| J6O25_RS24635 | 30377..30595 | + | 219 | Protein_42 | IS110 family transposase | - |
| J6O25_RS24640 (J6O25_24515) | 30915..31007 | + | 93 | Protein_43 | plasmid partition protein ParG | - |
| J6O25_RS24645 (J6O25_24520) | 31145..31429 | - | 285 | WP_000277490.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J6O25_RS24650 (J6O25_24525) | 31422..31664 | - | 243 | WP_000124732.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| J6O25_RS24655 (J6O25_24530) | 32237..33001 | - | 765 | WP_000076190.1 | plasmid replication initiator RepA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..303843 | 303843 | |
| - | inside | IScluster/Tn | - | - | 17464..34920 | 17456 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15164.56 Da Isoelectric Point: 6.4581
>T213059 WP_088765932.1 NZ_CP081691:28036-28452 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPDLVLEDWVR
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPDLVLEDWVR
Download Length: 417 bp
>T213059 NZ_CP107442:c149694-149203 [Klebsiella pneumoniae]
GTGGGCAAAGTAACGGCTCCGGTCCCACTCGGTACGTCACACATCCTCGCTGAGTTTCACTGTGGTGAGCCTGTACTGGA
CGAATGGATAAAGCACCGGGGACTAAAAAATCAGTCCCTGGGGGCGGCCAGAACGTTTGTGGTGTGCCGGGGAAATGCTT
CACAGGTGCTTGCCTACTACTCTCTCGCGACCGGCAGCGTCACTCATGCCATTGCGCCGGGAAGCCTGCGAAGGAATATG
CCCGATCCTGTACCTGTCATCATCCTGGCCCGTCTTGCTGTCGATACGAGTTATCACGGCCAGGGACTGGGGGCTGATTT
ACTGCATGATGCCGTATTACGTTGCTGTCGGGTGGCTGAGAACATTGGCGTGCGGGCCGTTATGGTTCATGCACTCTCTG
ACAGTGCCAGACAGTTCTACATACATCACGGATTTATCCCTTCACAAACGCAGGATAGAACCCTTTTTTTACGGTTGCCT
CTCATTACTTAG
GTGGGCAAAGTAACGGCTCCGGTCCCACTCGGTACGTCACACATCCTCGCTGAGTTTCACTGTGGTGAGCCTGTACTGGA
CGAATGGATAAAGCACCGGGGACTAAAAAATCAGTCCCTGGGGGCGGCCAGAACGTTTGTGGTGTGCCGGGGAAATGCTT
CACAGGTGCTTGCCTACTACTCTCTCGCGACCGGCAGCGTCACTCATGCCATTGCGCCGGGAAGCCTGCGAAGGAATATG
CCCGATCCTGTACCTGTCATCATCCTGGCCCGTCTTGCTGTCGATACGAGTTATCACGGCCAGGGACTGGGGGCTGATTT
ACTGCATGATGCCGTATTACGTTGCTGTCGGGTGGCTGAGAACATTGGCGTGCGGGCCGTTATGGTTCATGCACTCTCTG
ACAGTGCCAGACAGTTCTACATACATCACGGATTTATCCCTTCACAAACGCAGGATAGAACCCTTTTTTTACGGTTGCCT
CTCATTACTTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8756.83 Da Isoelectric Point: 4.4692
>AT213059 WP_001261282.1 NZ_CP081691:27809-28039 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL
Download Length: 231 bp
>AT213059 NZ_CP107442:c149948-149682 [Klebsiella pneumoniae]
ATGAAATCTGATGTTCAGCTCAACATCCGGGCGAAAGAAGCCCAGCGGGCTCTGATTGATACTGCCGCTGAGATTCTCCA
CAAATCACGCACTGATTTTATACTGGAGATGGCCTGTCAGGCGGCGGAAAACGTCATTCTTGACCGCCGTATGTTCAATC
TCAATGATGAACAGTACGCCGAGTTTATCGACATGCTGGATGCGCCGGTCACCGCTAACCCGGCGATGGAGAAACTCCTG
GCGAGAAAACCGCAGTGGGCAAAGTAA
ATGAAATCTGATGTTCAGCTCAACATCCGGGCGAAAGAAGCCCAGCGGGCTCTGATTGATACTGCCGCTGAGATTCTCCA
CAAATCACGCACTGATTTTATACTGGAGATGGCCTGTCAGGCGGCGGAAAACGTCATTCTTGACCGCCGTATGTTCAATC
TCAATGATGAACAGTACGCCGAGTTTATCGACATGCTGGATGCGCCGGTCACCGCTAACCCGGCGATGGAGAAACTCCTG
GCGAGAAAACCGCAGTGGGCAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|