Detailed information of TA system TA213040

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1231633..1232303
• Replicon: chromosome
• Accession: NZ_CP081690
• Organism: Escherichia coli strain 0H25

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: J6O25_RS06085
• Protein ID: WP_016243791.1
• Coordinates: 1231633..1231962 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: J6O25_RS06090
• Protein ID: WP_016243790.1
• Coordinates: 1231983..1232303 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6O25_RS06065 (1226687)	1226687..1227271	+	585	WP_016243792.1	tail fiber assembly protein	-
J6O25_RS06070 (1227341)	1227341..1228114	-	774	WP_000355482.1	hypothetical protein	-
J6O25_RS06075 (1228521)	1228521..1229954	+	1434	WP_001288444.1	DNA cytosine methyltransferase	-
J6O25_RS06080 (1229989)	1229989..1231203	-	1215	WP_012602456.1	type II restriction endonuclease	-
J6O25_RS06085 (1231633)	1231633..1231962	-	330	WP_016243791.1	TA system toxin CbtA family protein	Toxin
J6O25_RS06090 (1231983)	1231983..1232303	-	321	WP_016243790.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
J6O25_RS06095 (1232321)	1232321..1232542	-	222	WP_016243789.1	DUF987 domain-containing protein	-
J6O25_RS06100 (1232551)	1232551..1233033	-	483	WP_016243788.1	DNA repair protein RadC	-
J6O25_RS06105 (1233042)	1233042..1233500	-	459	WP_016243787.1	antirestriction protein	-
J6O25_RS06110 (1233663)	1233663..1233754	-	92	Protein_1195	DUF905 domain-containing protein	-
J6O25_RS06115 (1233988)	1233988..1234724	+	737	Protein_1196	IS3 family transposase	-
J6O25_RS06120 (1235397)	1235397..1236905	+	1509	WP_001189123.1	group II intron reverse transcriptase/maturase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1187569..1269526	81957

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-107)

Antitoxin

• Antitoxin CbeA (6-105)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12312.37 Da
• Isoelectric Point: 9.5496

>T213040 WP_016243791.1 NZ_CP081690:c1231962-1231633 [Escherichia coli]
MKTLPATISRAAKPCLTPVAAWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVDKYELVRIDRKGF
SWQEQTPYLSVVDILRARRSTGLLKAKVK

Nucleotide

• Length: 330 bp

>T213040 NZ_CP107437:c49365-48883 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11874.45 Da
• Isoelectric Point: 7.3231

>AT213040 WP_016243790.1 NZ_CP081690:c1232303-1231983 [Escherichia coli]
MRSNATWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDAAFPHFISQMESMLTTGEMNSRHAHCAILY
HNGFTCEADTLGSCGYVYIAIYSTQR

Nucleotide

• Length: 321 bp

>AT213040 NZ_CP107437:c49619-49353 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA