Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2941871..2942460 Replicon chromosome
Accession NC_007517
Organism Geobacter metallireducens GS-15

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GMET_RS13010 Protein ID WP_081431817.1
Coordinates 2942206..2942460 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q39SG4
Locus tag GMET_RS13005 Protein ID WP_004514790.1
Coordinates 2941871..2942209 (-) Length 113 a.a.

Genomic Context

GMET_RS12980GMET_RS12985GMET_RS12990GMET_RS12995GMET_RS13000GMET_RS18440GMET_RS13020GMET_RS13025GMET_RS13005GMET_RS13010GMET_RS13015GMET_RS13030
Location: 2937494..2937835 (342 bp)
Type: Others
Protein ID: WP_081431816.1
Location: 2937906..2938931 (1026 bp)
Type: Others
Protein ID: WP_004514801.1
Location: 2938928..2939722 (795 bp)
Type: Others
Protein ID: WP_004514800.1
Location: 2939767..2940255 (489 bp)
Type: Others
Protein ID: WP_049756810.1
Location: 2940552..2941100 (549 bp)
Type: Others
Protein ID: WP_004514792.1
Location: 2941200..2941724 (525 bp)
Type: Others
Protein ID: WP_004514791.1
Location: 2944016..2944978 (963 bp)
Type: Others
Protein ID: WP_004511867.1
Location: 2945175..2945687 (513 bp)
Type: Others
Protein ID: WP_011366073.1
Location: 2941871..2942209 (339 bp)
Type: Antitoxin
Protein ID: WP_004514790.1
Location: 2942206..2942460 (255 bp)
Type: Toxin
Protein ID: WP_081431817.1
Location: 2942698..2943867 (1170 bp)
Type: Others
Protein ID: WP_011365616.1
Location: 2945688..2946422 (735 bp)
Type: Others
Protein ID: WP_004511865.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GMET_RS129802937494..2937835+342WP_081431816.1pentapeptide repeat-containing protein-
GMET_RS129852937906..2938931+1026WP_004514801.1IS21-like element ISGme4 family transposase-
GMET_RS129902938928..2939722+795WP_004514800.1IS21-like element ISGme4 family helper ATPase IstB-
GMET_RS129952939767..2940255+489WP_049756810.1pentapeptide repeat-containing protein-
GMET_RS130002940552..2941100+549WP_004514792.1hypothetical protein-
GMET_RS184402941200..2941724+525WP_004514791.1DUF4410 domain-containing protein-
GMET_RS130052941871..2942209-339WP_004514790.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
GMET_RS130102942206..2942460-255WP_081431817.1type II toxin-antitoxin system HicA family toxinToxin
GMET_RS130152942698..2943867-1170WP_011365616.1IS481-like element ISGme9 family transposase-
GMET_RS130202944016..2944978+963WP_004511867.1SGNH/GDSL hydrolase family protein-
GMET_RS130252945175..2945687+513WP_011366073.1hypothetical protein-
GMET_RS130302945688..2946422-735WP_004511865.1NADH-quinone oxidoreductase subunit NuoB-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIScluster/Tn--2937906..29431205214


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9527.97 Da        Isoelectric Point: 10.6470

>T21304 WP_081431817.1 NC_007517:c2942460-2942206 [Geobacter metallireducens GS-15]
MKRKNLKTLESIFAHPVPGNVQWPDILALFKELGAEITEREGSRVGVRLFGDRRVFHRPHPSPDTDKGAVASIRKWLEEN
GVKP

Download         Length: 255 bp

>T21304 NC_007517:c2942460-2942206 [Geobacter metallireducens GS-15]
ATGAAAAGAAAAAATCTCAAAACACTGGAATCGATCTTTGCTCACCCGGTTCCCGGTAACGTTCAGTGGCCGGATATTCT
TGCACTTTTCAAAGAGCTTGGGGCTGAGATCACCGAGCGAGAAGGTTCCCGCGTCGGGGTTCGTCTATTTGGTGATCGAC
GAGTATTCCACCGTCCACATCCTTCGCCGGACACGGACAAAGGAGCAGTCGCTTCCATTCGGAAGTGGCTTGAAGAGAAT
GGAGTGAAACCATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12399.03 Da        Isoelectric Point: 5.1460

>AT21304 WP_004514790.1 NC_007517:c2942209-2941871 [Geobacter metallireducens GS-15]
MNNMTINDYDAVISYDPEINMFRGEFVGINGGADFYASTVDDLRKEGEISLKAFLEMCAEEGVEPRKHFSGKFNLRVPPA
LHQRLAAQAAAHGKSINAWVVELLSECAVRGH

Download         Length: 339 bp

>AT21304 NC_007517:c2942209-2941871 [Geobacter metallireducens GS-15]
ATGAACAATATGACCATAAACGACTATGACGCAGTCATTTCATATGACCCGGAAATCAACATGTTCCGGGGAGAGTTTGT
TGGAATCAATGGTGGTGCAGACTTCTACGCAAGTACTGTTGACGATCTTCGGAAAGAAGGCGAAATATCCCTCAAGGCTT
TTCTCGAAATGTGCGCCGAAGAAGGGGTTGAGCCGCGCAAACACTTCTCCGGAAAGTTCAACTTGCGGGTACCTCCCGCG
TTGCATCAGCGACTCGCTGCACAAGCTGCTGCTCACGGCAAGAGTATCAATGCCTGGGTTGTTGAACTCTTGTCAGAGTG
TGCAGTTCGCGGCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ39SG4

References