Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 218071..218590 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP081685 | ||
| Organism | Escherichia coli strain 0H23 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A837F4A9 |
| Locus tag | J6O16_RS25585 | Protein ID | WP_000277490.1 |
| Coordinates | 218306..218590 (+) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A6P1V8C3 |
| Locus tag | J6O16_RS25580 | Protein ID | WP_000124732.1 |
| Coordinates | 218071..218313 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J6O16_RS25560 (J6O16_25475) | 213796..213906 | + | 111 | Protein_226 | recombinase family protein | - |
| J6O16_RS25565 (J6O16_25480) | 213968..214672 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| J6O16_RS25570 (J6O16_25485) | 214734..216668 | + | 1935 | Protein_228 | Tn3 family transposase | - |
| J6O16_RS25575 (J6O16_25490) | 216686..217498 | + | 813 | WP_257606735.1 | plasmid replication initiator RepA | - |
| J6O16_RS25580 (J6O16_25495) | 218071..218313 | + | 243 | WP_000124732.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| J6O16_RS25585 (J6O16_25500) | 218306..218590 | + | 285 | WP_000277490.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J6O16_RS25590 (J6O16_25505) | 218728..218820 | - | 93 | Protein_232 | plasmid partition protein ParG | - |
| J6O16_RS25595 | 219140..219358 | - | 219 | Protein_233 | IS110 family transposase | - |
| J6O16_RS25600 (J6O16_25510) | 219359..219658 | - | 300 | Protein_234 | glycogen/starch synthase | - |
| J6O16_RS25605 (J6O16_25515) | 219658..220179 | - | 522 | Protein_235 | glucose-1-phosphate adenylyltransferase | - |
| J6O16_RS25610 (J6O16_25520) | 220242..220946 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| J6O16_RS25615 (J6O16_25525) | 221045..221185 | + | 141 | WP_045286941.1 | helix-turn-helix domain-containing protein | - |
| J6O16_RS25620 (J6O16_25530) | 221283..221699 | - | 417 | WP_088765932.1 | type II toxin-antitoxin system VapC family toxin | - |
| J6O16_RS25625 (J6O16_25535) | 221696..221926 | - | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| J6O16_RS25630 (J6O16_25540) | 221883..222344 | + | 462 | WP_223584524.1 | hypothetical protein | - |
| J6O16_RS25635 (J6O16_25545) | 222488..222838 | + | 351 | WP_000493399.1 | hypothetical protein | - |
| J6O16_RS27045 | 222882..223004 | + | 123 | WP_257606738.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..303841 | 303841 | |
| - | inside | IScluster/Tn | - | - | 213968..248557 | 34589 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11005.52 Da Isoelectric Point: 6.2103
>T213029 WP_000277490.1 NZ_CP081685:218306-218590 [Escherichia coli]
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL
Download Length: 285 bp
>T213029 NZ_CP107435:c6004-5690 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8875.01 Da Isoelectric Point: 7.0130
>AT213029 WP_000124732.1 NZ_CP081685:218071-218313 [Escherichia coli]
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV
Download Length: 243 bp
>AT213029 NZ_CP107435:c6270-5992 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A837F4A9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V8C3 |