213010

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1231633..1232303 Replicon chromosome
Accession NZ_CP081684
Organism Escherichia coli strain 0H23

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag J6O16_RS06085 Protein ID WP_016243791.1
Coordinates 1231633..1231962 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag J6O16_RS06090 Protein ID WP_016243790.1
Coordinates 1231983..1232303 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O16_RS06065 (1226687) 1226687..1227271 + 585 WP_016243792.1 tail fiber assembly protein -
J6O16_RS06070 (1227341) 1227341..1228114 - 774 WP_000355482.1 hypothetical protein -
J6O16_RS06075 (1228521) 1228521..1229954 + 1434 WP_001288444.1 DNA cytosine methyltransferase -
J6O16_RS06080 (1229989) 1229989..1231203 - 1215 WP_012602456.1 type II restriction endonuclease -
J6O16_RS06085 (1231633) 1231633..1231962 - 330 WP_016243791.1 TA system toxin CbtA family protein Toxin
J6O16_RS06090 (1231983) 1231983..1232303 - 321 WP_016243790.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J6O16_RS06095 (1232321) 1232321..1232542 - 222 WP_016243789.1 DUF987 domain-containing protein -
J6O16_RS06100 (1232551) 1232551..1233033 - 483 WP_016243788.1 DNA repair protein RadC -
J6O16_RS06105 (1233042) 1233042..1233500 - 459 WP_016243787.1 antirestriction protein -
J6O16_RS06110 (1233663) 1233663..1233754 - 92 Protein_1195 DUF905 domain-containing protein -
J6O16_RS06115 (1233988) 1233988..1234724 + 737 Protein_1196 IS3 family transposase -
J6O16_RS06120 (1235397) 1235397..1236905 + 1509 WP_001189123.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1187569..1269526 81957


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(6-105)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12312.37 Da        Isoelectric Point: 9.5496

>T213010 WP_016243791.1 NZ_CP081684:c1231962-1231633 [Escherichia coli]
MKTLPATISRAAKPCLTPVAAWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVDKYELVRIDRKGF
SWQEQTPYLSVVDILRARRSTGLLKAKVK

Download         Length: 330 bp

>T213010 NZ_CP107431:1088-1354 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11874.45 Da        Isoelectric Point: 7.3231

>AT213010 WP_016243790.1 NZ_CP081684:c1232303-1231983 [Escherichia coli]
MRSNATWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDAAFPHFISQMESMLTTGEMNSRHAHCAILY
HNGFTCEADTLGSCGYVYIAIYSTQR

Download         Length: 321 bp

>AT213010 NZ_CP107431:880-1104 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References