Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 2843788..2844359 Replicon chromosome
Accession NC_007517
Organism Geobacter metallireducens GS-15

Toxin (Protein)


Gene name mazF Uniprot ID Q39SQ0
Locus tag GMET_RS12580 Protein ID WP_004514645.1
Coordinates 2843788..2844042 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GMET_RS12585 Protein ID WP_011366065.1
Coordinates 2844030..2844359 (+) Length 110 a.a.

Genomic Context

GMET_RS12570GMET_RS12575GMET_RS18415GMET_RS18420GMET_RS12580GMET_RS12585GMET_RS18620GMET_RS12590GMET_RS12605GMET_RS12565GMET_RS12595GMET_RS12600
Location: 2840812..2842764 (1953 bp)
Type: Others
Protein ID: WP_004514648.1
Location: 2842903..2843172 (270 bp)
Type: Others
Protein ID: WP_004514647.1
Location: 2843184..2843441 (258 bp)
Type: Others
Protein ID: WP_004514646.1
Location: 2843469..2843594 (126 bp)
Type: Others
Protein ID: WP_081431800.1
Location: 2843788..2844042 (255 bp)
Type: Toxin
Protein ID: WP_004514645.1
Location: 2844030..2844359 (330 bp)
Type: Antitoxin
Protein ID: WP_011366065.1
Location: 2844507..2844674 (168 bp)
Type: Others
Protein ID: WP_004514643.1
Location: 2844932..2845459 (528 bp)
Type: Others
Protein ID: WP_004514642.1
Location: 2847872..2849263 (1392 bp)
Type: Others
Protein ID: WP_004514778.1
Location: 2839090..2840565 (1476 bp)
Type: Others
Protein ID: WP_004514649.1
Location: 2845490..2846440 (951 bp)
Type: Others
Protein ID: WP_004514641.1
Location: 2846500..2847669 (1170 bp)
Type: Others
Protein ID: WP_004514806.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GMET_RS125652839090..2840565-1476WP_004514649.1anthranilate synthase component I-
GMET_RS125702840812..2842764+1953WP_004514648.1molecular chaperone HtpG-
GMET_RS125752842903..2843172+270WP_004514647.1DUF4160 domain-containing protein-
GMET_RS184152843184..2843441+258WP_004514646.1DUF2442 domain-containing protein-
GMET_RS184202843469..2843594+126WP_081431800.1DUF3387 domain-containing protein-
GMET_RS125802843788..2844042+255WP_004514645.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinToxin
GMET_RS125852844030..2844359+330WP_011366065.1type II toxin-antitoxin system PemK/MazF family toxinAntitoxin
GMET_RS186202844507..2844674+168WP_004514643.1hypothetical protein-
GMET_RS125902844932..2845459+528WP_004514642.1L,D-transpeptidase family protein-
GMET_RS125952845490..2846440-951WP_004514641.1rhomboid family intramembrane serine protease-
GMET_RS126002846500..2847669-1170WP_004514806.1IS4-like element ISGme2 family transposase-
GMET_RS126052847872..2849263+1392WP_004514778.1MATE family efflux transporter-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--2846500..28476691169


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

SpoVT-AbrB domain

(7-48)

Antitoxin

mRNA interferase PemK-like

(3-106)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9723.85 Da        Isoelectric Point: 4.3535

>T21301 WP_004514645.1 NC_007517:2843788-2844042 [Geobacter metallireducens GS-15]
MRTNIIRIGNSQGIRIPKVLLEQSHLGAEVELEVEDEKIIIRSASRPRQGWGEKFQLMAESGDDRMLNGDAGEQTEWDKD
EWEW

Download         Length: 255 bp

>T21301 NC_007517:2843788-2844042 [Geobacter metallireducens GS-15]
ATGAGGACCAACATTATTCGCATAGGCAATTCCCAAGGCATCCGAATCCCTAAGGTTCTCCTGGAACAGAGCCATCTCGG
AGCAGAGGTGGAGTTGGAGGTGGAGGATGAGAAAATCATCATCCGCTCCGCTTCCCGCCCTCGCCAGGGGTGGGGGGAGA
AATTCCAGCTCATGGCTGAGAGCGGCGATGACAGAATGCTTAACGGGGATGCGGGCGAGCAGACCGAATGGGACAAGGAT
GAATGGGAATGGTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12446.62 Da        Isoelectric Point: 9.5798

>AT21301 WP_011366065.1 NC_007517:2844030-2844359 [Geobacter metallireducens GS-15]
MGMVVKRFDVYLVNLDPTVGREIRKARPCLIISPDEMNRYIGTVIVAPMTTKGRDYPTRVQCSFKGKEGQVVLDQIRTVD
KSRLFQKLGRIDKETQEEVLSILAEMFAP

Download         Length: 330 bp

>AT21301 NC_007517:2844030-2844359 [Geobacter metallireducens GS-15]
ATGGGAATGGTAGTCAAACGCTTCGACGTCTATCTGGTCAACCTGGACCCCACCGTCGGCAGGGAGATTCGCAAGGCAAG
GCCATGTCTCATTATCTCACCCGATGAAATGAACCGGTACATCGGCACCGTTATCGTTGCCCCCATGACCACCAAAGGGA
GGGATTATCCCACGCGGGTGCAGTGCTCCTTCAAGGGCAAGGAGGGACAGGTTGTCCTTGACCAGATCAGAACCGTGGAC
AAGTCCCGTCTTTTCCAGAAGCTCGGAAGAATCGACAAAGAAACGCAGGAAGAGGTGTTGTCCATTCTTGCGGAGATGTT
TGCGCCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ39SQ0

Antitoxin

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Source
ID
Structure
No matching records found

References