Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 6475..6994 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP081678 | ||
| Organism | Escherichia coli strain 0H15 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A837F4A9 |
| Locus tag | J6O45_RS24500 | Protein ID | WP_000277490.1 |
| Coordinates | 6475..6759 (-) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A6P1V8C3 |
| Locus tag | J6O45_RS24505 | Protein ID | WP_000124732.1 |
| Coordinates | 6752..6994 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J6O45_RS27130 | 2061..2183 | - | 123 | WP_257606738.1 | hypothetical protein | - |
| J6O45_RS24450 (J6O45_24325) | 2227..2577 | - | 351 | WP_000493399.1 | hypothetical protein | - |
| J6O45_RS24455 (J6O45_24330) | 2721..3182 | - | 462 | WP_223584524.1 | hypothetical protein | - |
| J6O45_RS24460 (J6O45_24335) | 3139..3369 | + | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| J6O45_RS24465 (J6O45_24340) | 3366..3782 | + | 417 | WP_088765932.1 | type II toxin-antitoxin system VapC family toxin | - |
| J6O45_RS24470 (J6O45_24345) | 3880..4020 | - | 141 | WP_045286941.1 | helix-turn-helix domain-containing protein | - |
| J6O45_RS24475 (J6O45_24350) | 4119..4823 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| J6O45_RS24480 (J6O45_24355) | 4886..5407 | + | 522 | Protein_10 | glucose-1-phosphate adenylyltransferase | - |
| J6O45_RS24485 (J6O45_24360) | 5407..5706 | + | 300 | Protein_11 | glycogen/starch synthase | - |
| J6O45_RS24490 | 5707..5925 | + | 219 | Protein_12 | IS110 family transposase | - |
| J6O45_RS24495 (J6O45_24365) | 6245..6337 | + | 93 | Protein_13 | plasmid partition protein ParG | - |
| J6O45_RS24500 (J6O45_24370) | 6475..6759 | - | 285 | WP_000277490.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J6O45_RS24505 (J6O45_24375) | 6752..6994 | - | 243 | WP_000124732.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| J6O45_RS24510 (J6O45_24380) | 7567..8379 | - | 813 | WP_257606735.1 | plasmid replication initiator RepA | - |
| J6O45_RS24515 (J6O45_24385) | 8397..10331 | - | 1935 | Protein_17 | Tn3 family transposase | - |
| J6O45_RS24520 (J6O45_24390) | 10393..11097 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| J6O45_RS24525 (J6O45_24395) | 11159..11269 | - | 111 | Protein_19 | recombinase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..303841 | 303841 | |
| - | inside | IScluster/Tn | - | - | 98..11097 | 10999 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11005.52 Da Isoelectric Point: 6.2103
>T213000 WP_000277490.1 NZ_CP081678:c6759-6475 [Escherichia coli]
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL
Download Length: 285 bp
>T213000 NZ_CP107426:3286803-3287087 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8875.01 Da Isoelectric Point: 7.0130
>AT213000 WP_000124732.1 NZ_CP081678:c6994-6752 [Escherichia coli]
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV
Download Length: 243 bp
>AT213000 NZ_CP107426:3286571-3286813 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A837F4A9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V8C3 |