Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3700974..3701592 Replicon chromosome
Accession NZ_CP081677
Organism Escherichia coli strain 0H15

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag J6O45_RS18095 Protein ID WP_001291435.1
Coordinates 3701374..3701592 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag J6O45_RS18090 Protein ID WP_000344800.1
Coordinates 3700974..3701348 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O45_RS18080 (3696063) 3696063..3697256 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
J6O45_RS18085 (3697279) 3697279..3700428 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
J6O45_RS18090 (3700974) 3700974..3701348 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
J6O45_RS18095 (3701374) 3701374..3701592 + 219 WP_001291435.1 HHA domain-containing protein Toxin
J6O45_RS18100 (3701764) 3701764..3702315 + 552 WP_000102564.1 maltose O-acetyltransferase -
J6O45_RS18105 (3702431) 3702431..3702901 + 471 WP_000136192.1 YlaC family protein -
J6O45_RS18110 (3703065) 3703065..3704615 + 1551 WP_001514985.1 cyclic-guanylate-specific phosphodiesterase PdeB -
J6O45_RS18115 (3704657) 3704657..3705010 - 354 WP_000878140.1 DUF1428 domain-containing protein -
J6O45_RS18125 (3705389) 3705389..3705700 + 312 WP_000409911.1 MGMT family protein -
J6O45_RS18130 (3705731) 3705731..3706303 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T212992 WP_001291435.1 NZ_CP081677:3701374-3701592 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T212992 NZ_CP107424:c4371-4057 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT212992 WP_000344800.1 NZ_CP081677:3700974-3701348 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT212992 NZ_CP107424:c4637-4359 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References