Detailed information of TA system TA212980

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1231634..1232304
• Replicon: chromosome
• Accession: NZ_CP081677
• Organism: Escherichia coli strain 0H15

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: J6O45_RS06090
• Protein ID: WP_016243791.1
• Coordinates: 1231634..1231963 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: J6O45_RS06095
• Protein ID: WP_016243790.1
• Coordinates: 1231984..1232304 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6O45_RS06070 (1226688)	1226688..1227272	+	585	WP_016243792.1	tail fiber assembly protein	-
J6O45_RS06075 (1227342)	1227342..1228115	-	774	WP_000355482.1	hypothetical protein	-
J6O45_RS06080 (1228522)	1228522..1229955	+	1434	WP_001288444.1	DNA cytosine methyltransferase	-
J6O45_RS06085 (1229990)	1229990..1231204	-	1215	WP_012602456.1	type II restriction endonuclease	-
J6O45_RS06090 (1231634)	1231634..1231963	-	330	WP_016243791.1	TA system toxin CbtA family protein	Toxin
J6O45_RS06095 (1231984)	1231984..1232304	-	321	WP_016243790.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
J6O45_RS06100 (1232322)	1232322..1232543	-	222	WP_016243789.1	DUF987 domain-containing protein	-
J6O45_RS06105 (1232552)	1232552..1233034	-	483	WP_016243788.1	DNA repair protein RadC	-
J6O45_RS06110 (1233043)	1233043..1233501	-	459	WP_016243787.1	antirestriction protein	-
J6O45_RS06115 (1233664)	1233664..1233755	-	92	Protein_1196	DUF905 domain-containing protein	-
J6O45_RS06120 (1233989)	1233989..1234725	+	737	Protein_1197	IS3 family transposase	-
J6O45_RS06125 (1235398)	1235398..1236906	+	1509	WP_001189123.1	group II intron reverse transcriptase/maturase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1187570..1269527	81957

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-107)

Antitoxin

• Antitoxin CbeA (6-105)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12312.37 Da
• Isoelectric Point: 9.5496

>T212980 WP_016243791.1 NZ_CP081677:c1231963-1231634 [Escherichia coli]
MKTLPATISRAAKPCLTPVAAWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVDKYELVRIDRKGF
SWQEQTPYLSVVDILRARRSTGLLKAKVK

Nucleotide

• Length: 330 bp

>T212980 NZ_CP081677:c1231963-1231634 [Escherichia coli]
ATGAAAACTCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGTCTGACGCCCGTGGCTGCCTGGCAAATGTTACTGAC
ACGTCTGCTAGAACAGCACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATTG
ATGCAGGGATCACCCTGGCCGATGCAGTCAACTTTCTGGTGGATAAGTACGAACTAGTTCGTATCGACCGGAAGGGATTT
TCGTGGCAAGAGCAGACCCCGTATCTTTCCGTAGTGGATATTCTGCGAGCAAGGCGCTCTACCGGATTGCTAAAAGCCAA
GGTGAAATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11874.45 Da
• Isoelectric Point: 7.3231

>AT212980 WP_016243790.1 NZ_CP081677:c1232304-1231984 [Escherichia coli]
MRSNATWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDAAFPHFISQMESMLTTGEMNSRHAHCAILY
HNGFTCEADTLGSCGYVYIAIYSTQR

Nucleotide

• Length: 321 bp

>AT212980 NZ_CP081677:c1232304-1231984 [Escherichia coli]
ATGAGGAGTAACGCTACATGGGGACTGCAACGTGATATCACACCGCGTCTGGGAGCCCGTCTGGTGCAGGAGGGCAACCG
GCTGCACTATCTGGCTGACCGGGCAAGTATCACAGGTAAGTTTAGTGATGCCGAATGCCTGAAGTTGGATGCCGCATTTC
CGCATTTTATCAGTCAGATGGAATCGATGCTGACCACTGGTGAAATGAACTCTCGCCATGCCCACTGCGCCATCCTGTAT
CACAACGGCTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCCATTTATTCCACTCAACGCTA
A